Structure and allosteric inhibition of excitatory amino acid transporter 1

Human members of the solute carrier 1 (SLC1) family of transporters take up excitatory neurotransmitters in the brain and amino acids in peripheral organs. Dysregulation of their functions is associated to neurodegenerative disorders and cancer. Here we present the first crystal structures of a ther...

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Detalles Bibliográficos
Autores principales: Canul-Tec, Juan C., Assal, Reda, Cirri, Erica, Legrand, Pierre, Brier, Sébastien, Chamot-Rooke, Julia, Reyes, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410168/
https://www.ncbi.nlm.nih.gov/pubmed/28424515
http://dx.doi.org/10.1038/nature22064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410168/
https://www.ncbi.nlm.nih.gov/pubmed/28424515
http://dx.doi.org/10.1038/nature22064

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