Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids

A series of rhodanine 3-carboxyalkanoic acid derivatives possessing 4′-(N,N-dialkyl-amino or diphenylamino)-benzylidene moiety as a substituent at the C-5 position were synthesised and their antibacterial activity was screened. All the rhodanine derivatives showed bacteriostatic or bactericidal acti...

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Autores principales: Tejchman, Waldemar, Korona-Glowniak, Izabela, Malm, Anna, Zylewski, Marek, Suder, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410203/
https://www.ncbi.nlm.nih.gov/pubmed/28515623
http://dx.doi.org/10.1007/s00044-017-1852-7
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author Tejchman, Waldemar
Korona-Glowniak, Izabela
Malm, Anna
Zylewski, Marek
Suder, Piotr
author_facet Tejchman, Waldemar
Korona-Glowniak, Izabela
Malm, Anna
Zylewski, Marek
Suder, Piotr
author_sort Tejchman, Waldemar
collection PubMed
description A series of rhodanine 3-carboxyalkanoic acid derivatives possessing 4′-(N,N-dialkyl-amino or diphenylamino)-benzylidene moiety as a substituent at the C-5 position were synthesised and their antibacterial activity was screened. All the rhodanine derivatives showed bacteriostatic or bactericidal activity to the reference gram-positive bacterial strains, but lack of activity to the reference Gram-negative bacterial strains and yeast strains was observed.
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spelling pubmed-54102032017-05-15 Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids Tejchman, Waldemar Korona-Glowniak, Izabela Malm, Anna Zylewski, Marek Suder, Piotr Med Chem Res Original Research A series of rhodanine 3-carboxyalkanoic acid derivatives possessing 4′-(N,N-dialkyl-amino or diphenylamino)-benzylidene moiety as a substituent at the C-5 position were synthesised and their antibacterial activity was screened. All the rhodanine derivatives showed bacteriostatic or bactericidal activity to the reference gram-positive bacterial strains, but lack of activity to the reference Gram-negative bacterial strains and yeast strains was observed. Springer US 2017-03-16 2017 /pmc/articles/PMC5410203/ /pubmed/28515623 http://dx.doi.org/10.1007/s00044-017-1852-7 Text en © The Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Tejchman, Waldemar
Korona-Glowniak, Izabela
Malm, Anna
Zylewski, Marek
Suder, Piotr
Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids
title Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids
title_full Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids
title_fullStr Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids
title_full_unstemmed Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids
title_short Antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids
title_sort antibacterial properties of 5-substituted derivatives of rhodanine-3-carboxyalkyl acids
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410203/
https://www.ncbi.nlm.nih.gov/pubmed/28515623
http://dx.doi.org/10.1007/s00044-017-1852-7
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