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Lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life

PURPOSE: Lymphedema is a chronic and disabling sequel of breast cancer treatment that can be treated by lymphatico-venous anastomosis (LVA). Artificial connections between the venous and lymphatic system are performed supermicrosurgically. This prospective study analyses the effect of LVA on quality...

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Autores principales: Cornelissen, Anouk J. M., Kool, Melissa, Lopez Penha, Tiara R., Keuter, Xavier H. A., Piatkowski, Andrzej A., Heuts, E., van der Hulst, René R. W. J., Qiu, Shan Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410204/
https://www.ncbi.nlm.nih.gov/pubmed/28265793
http://dx.doi.org/10.1007/s10549-017-4180-1
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author Cornelissen, Anouk J. M.
Kool, Melissa
Lopez Penha, Tiara R.
Keuter, Xavier H. A.
Piatkowski, Andrzej A.
Heuts, E.
van der Hulst, René R. W. J.
Qiu, Shan Shan
author_facet Cornelissen, Anouk J. M.
Kool, Melissa
Lopez Penha, Tiara R.
Keuter, Xavier H. A.
Piatkowski, Andrzej A.
Heuts, E.
van der Hulst, René R. W. J.
Qiu, Shan Shan
author_sort Cornelissen, Anouk J. M.
collection PubMed
description PURPOSE: Lymphedema is a chronic and disabling sequel of breast cancer treatment that can be treated by lymphatico-venous anastomosis (LVA). Artificial connections between the venous and lymphatic system are performed supermicrosurgically. This prospective study analyses the effect of LVA on quality of life. METHODS: A prospective study was performed between November 2015 and July 2016 on consecutive patients in the Maastricht University Medical Centre. Quality of life was considered as the primary outcome, and the Lymphedema International Classification of Functioning (Lymph-ICF) questionnaire was used. Discontinuation of compressive stockings and arm volume, using the Upper Extremity Lymphedema index (UEL-index), were the secondary outcomes. RESULTS: Twenty women with early-stage breast cancer-related lymphedema (BCRL) were included. The mean age was 55.9 ± 4 years and the median BMI was 25.1 [21–30] kg/m(2). The mean follow-up was 7.8 ± 1.5 months. Statistically significant improvement in quality of life was achieved in the total score and for all the quality of life domains after one year of follow-up (p < 0.05). The discontinuation rate in compressive stockings use was 85%. The difference in mean relative volume did not show a statistically significant decrease. CONCLUSIONS: LVA for early-stage BCRL resulted in a significant improvement in quality of life and a high rate in stocking discontinuation.
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spelling pubmed-54102042017-05-15 Lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life Cornelissen, Anouk J. M. Kool, Melissa Lopez Penha, Tiara R. Keuter, Xavier H. A. Piatkowski, Andrzej A. Heuts, E. van der Hulst, René R. W. J. Qiu, Shan Shan Breast Cancer Res Treat Clinical Trial PURPOSE: Lymphedema is a chronic and disabling sequel of breast cancer treatment that can be treated by lymphatico-venous anastomosis (LVA). Artificial connections between the venous and lymphatic system are performed supermicrosurgically. This prospective study analyses the effect of LVA on quality of life. METHODS: A prospective study was performed between November 2015 and July 2016 on consecutive patients in the Maastricht University Medical Centre. Quality of life was considered as the primary outcome, and the Lymphedema International Classification of Functioning (Lymph-ICF) questionnaire was used. Discontinuation of compressive stockings and arm volume, using the Upper Extremity Lymphedema index (UEL-index), were the secondary outcomes. RESULTS: Twenty women with early-stage breast cancer-related lymphedema (BCRL) were included. The mean age was 55.9 ± 4 years and the median BMI was 25.1 [21–30] kg/m(2). The mean follow-up was 7.8 ± 1.5 months. Statistically significant improvement in quality of life was achieved in the total score and for all the quality of life domains after one year of follow-up (p < 0.05). The discontinuation rate in compressive stockings use was 85%. The difference in mean relative volume did not show a statistically significant decrease. CONCLUSIONS: LVA for early-stage BCRL resulted in a significant improvement in quality of life and a high rate in stocking discontinuation. Springer US 2017-03-07 2017 /pmc/articles/PMC5410204/ /pubmed/28265793 http://dx.doi.org/10.1007/s10549-017-4180-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Clinical Trial
Cornelissen, Anouk J. M.
Kool, Melissa
Lopez Penha, Tiara R.
Keuter, Xavier H. A.
Piatkowski, Andrzej A.
Heuts, E.
van der Hulst, René R. W. J.
Qiu, Shan Shan
Lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life
title Lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life
title_full Lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life
title_fullStr Lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life
title_full_unstemmed Lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life
title_short Lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life
title_sort lymphatico-venous anastomosis as treatment for breast cancer-related lymphedema: a prospective study on quality of life
topic Clinical Trial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410204/
https://www.ncbi.nlm.nih.gov/pubmed/28265793
http://dx.doi.org/10.1007/s10549-017-4180-1
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