Synergistic induction of apoptosis by salinomycin and gefitinib through lysosomal and mitochondrial dependent pathway overcomes gefitinib resistance in colorectal cancer

Here, we showed the antibiotic salinomycin (SAL) combined with GEF exerted synergistic cytotoxicity effects in colorectal cancer cells irrespective of their EGFR and KRAS status, with a relatively low toxicity to normal cells. Additionally, combination of the two drugs overcame Ras-induced resistanc...

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Detalles Bibliográficos
Autores principales: Zou, Zheng-Zhi, Nie, Pei-Pei, Li, Ya-Wei, Hou, Ben-Xin, Rui-Li, Shi, Xin-Peng, Ma, Zhao-Kui, Han, Bao-Wei, Luo, Xiao-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410233/
https://www.ncbi.nlm.nih.gov/pubmed/26461472
http://dx.doi.org/10.18632/oncotarget.5628

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