HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) is the rate-limiting enzyme of ketogenesis. Growing evidence indicates that HMGCS2 may be involved in cancer progression, but its exact role is largely unknown. In this study, we demonstrate that HMGCS2 mRNA expression is associated with...

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Detalles Bibliográficos
Autores principales: Chen, Shih-Wen, Chou, Chiang-Ting, Chang, Cheng-Chi, Li, Yue-Ju, Chen, Szu-Ta, Lin, I-Ching, Kok, Sang-Heng, Cheng, Shih-Jung, Lee, Jang-Jaer, Wu, Tai-Sheng, Kuo, Min-Liang, Lin, Been-Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410236/
https://www.ncbi.nlm.nih.gov/pubmed/27816970
http://dx.doi.org/10.18632/oncotarget.13006

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