Osteotropism of neuroendocrine tumors: role of the CXCL12/CXCR4 pathway in promoting EMT in vitro

Neuroendocrine tumors (NETs) metastasize to the skeleton in approximately 20% of patients. We have previously shown that the epithelial-mesenchymal transition (EMT) regulates the NET osteotropism and that CXCR4 overexpression predicts bone spreading. Here, we unravel the molecular mechanisms linking...

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Detalles Bibliográficos
Autores principales: Cives, Mauro, Quaresmini, Davide, Rizzo, Francesca Maria, Felici, Claudia, D'Oronzo, Stella, Simone, Valeria, Silvestris, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410243/
https://www.ncbi.nlm.nih.gov/pubmed/28186979
http://dx.doi.org/10.18632/oncotarget.15122

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