Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition

Metastatic cancer cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) to degrade the extracellular matrix in order to facilitate migration and proliferation. Tissue Inhibitor of Metalloproteinase (TIMP)-2 is the endogenous inhibitor of the MMP. Here, we describe a novel and highly effec...

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Detalles Bibliográficos
Autores principales: Jiang, Bingjie, Zhang, Yan, Liu, Jian, Tsigkou, Anastasia, Rapti, Magdalini, Lee, Meng Huee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410255/
https://www.ncbi.nlm.nih.gov/pubmed/28186971
http://dx.doi.org/10.18632/oncotarget.15165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410255/
https://www.ncbi.nlm.nih.gov/pubmed/28186971
http://dx.doi.org/10.18632/oncotarget.15165

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