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Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is a highly aggressive neoplasm. We aim to explore the anti-HCC activity by a natural prenylflavonoid icaritin. Icaritin was cytotoxic and pro-apoptotic when added to established (HepG2, KYN-2 and Huh-7 lines) and primary human HCC cells. At the signaling level, icarit...

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Detalles Bibliográficos
Autores principales:	Lu, Pei-Hua, Chen, Min-Bin, Liu, Yuan-Yuan, Wu, Mian-Hua, Li, Wen-Ting, Wei, Mu-Xin, Liu, Chao-Ying, Qin, Shu-Kui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410263/ https://www.ncbi.nlm.nih.gov/pubmed/28206952 http://dx.doi.org/10.18632/oncotarget.15205

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