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Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients

In order to explore the new mechanism that obesity worsens the prognosis of breast cancer, we reanalyzed the data about gene expression of normal, overweight, and obese breast cancer patients to explore potential genes and validate its function by clinical and experimental data. The fold change of 1...

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Autores principales: Wu, Ruxing, Liu, Tao, Yang, Peiwen, Liu, Xiyou, Liu, Fei, Wang, Ya, Xiong, Huihua, Yu, Shiying, Huang, Xiaoyuan, Zhuang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410267/
https://www.ncbi.nlm.nih.gov/pubmed/28206964
http://dx.doi.org/10.18632/oncotarget.15280
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author Wu, Ruxing
Liu, Tao
Yang, Peiwen
Liu, Xiyou
Liu, Fei
Wang, Ya
Xiong, Huihua
Yu, Shiying
Huang, Xiaoyuan
Zhuang, Liang
author_facet Wu, Ruxing
Liu, Tao
Yang, Peiwen
Liu, Xiyou
Liu, Fei
Wang, Ya
Xiong, Huihua
Yu, Shiying
Huang, Xiaoyuan
Zhuang, Liang
author_sort Wu, Ruxing
collection PubMed
description In order to explore the new mechanism that obesity worsens the prognosis of breast cancer, we reanalyzed the data about gene expression of normal, overweight, and obese breast cancer patients to explore potential genes and validate its function by clinical and experimental data. The fold change of 15-hydroxyprostaglandin dehydrogenate (HPGD) gene which displayed declining trend with BMI increase was 0.46 in obese versus normal weight patients. HPGD protein was highest expressed in normal weight group and lowest expressed in obese group. The rate of positive lymph nodes was 67% in low expression of HPGD group and 35% in high expression of HPGD group. The recurrence-free survival (RFS) rate and overall survival (OS) rate of 5 years had significant difference between low expression of HPGD group and high expression of HPGD group. Obesity dramatically decreased the RFS rate and OS rate of 5 years. Down regulation of HPGD expression could increase the migration and proliferation ability of breast cancer cell line MCF-7. Taken together, our results indicate that low expression of HPGD may be a reason for poor prognosis of obese breast cancer patients.
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spelling pubmed-54102672017-05-04 Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients Wu, Ruxing Liu, Tao Yang, Peiwen Liu, Xiyou Liu, Fei Wang, Ya Xiong, Huihua Yu, Shiying Huang, Xiaoyuan Zhuang, Liang Oncotarget Research Paper In order to explore the new mechanism that obesity worsens the prognosis of breast cancer, we reanalyzed the data about gene expression of normal, overweight, and obese breast cancer patients to explore potential genes and validate its function by clinical and experimental data. The fold change of 15-hydroxyprostaglandin dehydrogenate (HPGD) gene which displayed declining trend with BMI increase was 0.46 in obese versus normal weight patients. HPGD protein was highest expressed in normal weight group and lowest expressed in obese group. The rate of positive lymph nodes was 67% in low expression of HPGD group and 35% in high expression of HPGD group. The recurrence-free survival (RFS) rate and overall survival (OS) rate of 5 years had significant difference between low expression of HPGD group and high expression of HPGD group. Obesity dramatically decreased the RFS rate and OS rate of 5 years. Down regulation of HPGD expression could increase the migration and proliferation ability of breast cancer cell line MCF-7. Taken together, our results indicate that low expression of HPGD may be a reason for poor prognosis of obese breast cancer patients. Impact Journals LLC 2017-02-11 /pmc/articles/PMC5410267/ /pubmed/28206964 http://dx.doi.org/10.18632/oncotarget.15280 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Wu, Ruxing
Liu, Tao
Yang, Peiwen
Liu, Xiyou
Liu, Fei
Wang, Ya
Xiong, Huihua
Yu, Shiying
Huang, Xiaoyuan
Zhuang, Liang
Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients
title Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients
title_full Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients
title_fullStr Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients
title_full_unstemmed Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients
title_short Association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients
title_sort association of 15-hydroxyprostaglandin dehydrogenate and poor prognosis of obese breast cancer patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410267/
https://www.ncbi.nlm.nih.gov/pubmed/28206964
http://dx.doi.org/10.18632/oncotarget.15280
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