Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome

The interaction between acute myeloid leukemia cells (AML) with the bone marrow stroma cells (BMSCs) determines a protective environment that favors tumor development and resistance to conventional chemotherapy. We showed that BMSCs secrete soluble factors that protect AML cells from Ara-C induced c...

Descripción completa

Detalles Bibliográficos
Autores principales: Macanas-Pirard, Patricia, Broekhuizen, Richard, González, Alfonso, Oyanadel, Claudia, Ernst, Daniel, García, Patricia, Montecinos, Viviana P., Court, Felipe, Ocqueteau, Mauricio, Ramirez, Pablo, Nervi, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410286/
https://www.ncbi.nlm.nih.gov/pubmed/28160570
http://dx.doi.org/10.18632/oncotarget.14981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410286/
https://www.ncbi.nlm.nih.gov/pubmed/28160570
http://dx.doi.org/10.18632/oncotarget.14981

Ejemplares similares