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Resistance of leukemia cells to cytarabine chemotherapy is mediated by bone marrow stroma, involves cell-surface equilibrative nucleoside transporter-1 removal and correlates with patient outcome
The interaction between acute myeloid leukemia cells (AML) with the bone marrow stroma cells (BMSCs) determines a protective environment that favors tumor development and resistance to conventional chemotherapy. We showed that BMSCs secrete soluble factors that protect AML cells from Ara-C induced c...
Autores principales: | Macanas-Pirard, Patricia, Broekhuizen, Richard, González, Alfonso, Oyanadel, Claudia, Ernst, Daniel, García, Patricia, Montecinos, Viviana P., Court, Felipe, Ocqueteau, Mauricio, Ramirez, Pablo, Nervi, Bruno |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410286/ https://www.ncbi.nlm.nih.gov/pubmed/28160570 http://dx.doi.org/10.18632/oncotarget.14981 |
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