dUTPase inhibition augments replication defects of 5-Fluorouracil

The antimetabolite 5-Fluorouracil (5-FU) is used in the treatment of various forms of cancer and has a complex mode of action. Despite 6 decades in clinical application the contribution of 5-FdUTP and dUTP [(5-F)dUTP] and 5-FUTP misincorporation into DNA and RNA respectively, for 5-FU-induced toxici...

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Detalles Bibliográficos
Autores principales: Hagenkort, Anna, Paulin, Cynthia B.J., Desroses, Matthieu, Sarno, Antonio, Wiita, Elisée, Mortusewicz, Oliver, Koolmeister, Tobias, Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Homan, Evert, Lundbäck, Thomas, Gustavsson, Anna-Lena, Scobie, Martin, Helleday, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410339/
https://www.ncbi.nlm.nih.gov/pubmed/28423595
http://dx.doi.org/10.18632/oncotarget.15785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410339/
https://www.ncbi.nlm.nih.gov/pubmed/28423595
http://dx.doi.org/10.18632/oncotarget.15785

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