Ephrin-B3 supports glioblastoma growth by inhibiting apoptosis induced by the dependence receptor EphA4

EphA4, an Ephrins tyrosine kinase receptor, behaves as a dependence receptor (DR) by triggering cell apoptosis in the absence of its ligand Ephrin-B3. DRs act as conditional tumor suppressors, engaging cell death based on ligand availability; this mechanism is bypassed by overexpression of DRs ligan...

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Detalles Bibliográficos
Autores principales: Royet, Amélie, Broutier, Laura, Coissieux, Marie-May, Malleval, Céline, Gadot, Nicolas, Maillet, Denis, Gratadou-Hupon, Lise, Bernet, Agnès, Nony, Pascale, Treilleux, Isabelle, Honnorat, Jérôme, Liebl, Daniel, Pelletier, Laurent, Berger, François, Meyronet, David, Castets, Marie, Mehlen, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410341/
https://www.ncbi.nlm.nih.gov/pubmed/28423606
http://dx.doi.org/10.18632/oncotarget.16077

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