Systematic screening of isogenic cancer cells identifies DUSP6 as context-specific synthetic lethal target in melanoma

Next-generation sequencing has dramatically increased genome-wide profiling options and conceptually initiates the possibility for personalized cancer therapy. State-of-the-art sequencing studies yield large candidate gene sets comprising dozens or hundreds of mutated genes. However, few technologie...

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Detalles Bibliográficos
Autores principales: Wittig-Blaich, Stephanie, Wittig, Rainer, Schmidt, Steffen, Lyer, Stefan, Bewerunge-Hudler, Melanie, Gronert-Sum, Sabine, Strobel-Freidekind, Olga, Müller, Carolin, List, Markus, Jaskot, Aleksandra, Christiansen, Helle, Hafner, Mathias, Schadendorf, Dirk, Block, Ines, Mollenhauer, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410342/
https://www.ncbi.nlm.nih.gov/pubmed/28423600
http://dx.doi.org/10.18632/oncotarget.15863

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