Epstein-Barr Virus-associated Lymphoproliferative Disorder with Encephalitis Following Anti-thymocyte Globulin for Aplastic Anemia Resolved with Rituximab Therapy: A Case Report and Literature Review

Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) sometimes occur following Anti-thymocyte globulin (ATG) administration for allogenic stem cell transplantation but are rare in aplastic anemia (AA) patients. A 55-year-old woman with AA following ATG developed refractory fever...

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Detalles Bibliográficos
Autores principales: Mashima, Kiyomi, Yano, Shingo, Yokoyama, Hiroki, Saito, Takeshi, Machishima, Tomohito, Shimada, Takaki, Yahagi, Yuichi, Takahara, Shinobu, Sugiyama, Katsuki, Ogasawara, Yoji, Minami, Jiro, Kamiyama, Yutaro, Katsube, Atsushi, Suzuki, Kazuhito, Ohshima, Sayaka, Yamada, Hisashi, Usui, Noriko, Aiba, Keisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410484/
https://www.ncbi.nlm.nih.gov/pubmed/28321074
Descripción
Sumario:Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) sometimes occur following Anti-thymocyte globulin (ATG) administration for allogenic stem cell transplantation but are rare in aplastic anemia (AA) patients. A 55-year-old woman with AA following ATG developed refractory fever and was diagnosed with EBV-LPD. She was successfully treated with weekly rituximab monotherapy; however, she developed EBV encephalitis. She was admitted to the intensive care unit and finally recovered from unconsciousness. EBV-LPD should be considered after ATG for AA when symptoms appear. Because EBV-LPD following ATG for AA can rapidly progress, weekly monitoring of EBV-DNA and early intervention may be necessary.

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