Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011

BACKGROUND: Human enteroviruses (EV) have been associated with severe acute respiratory illness (SARI) in South Africa. OBJECTIVES: We aimed to describe the molecular epidemiology of EV serotypes among patients hospitalized with SARI during 2009‐2011. PATIENTS/METHODS: Study samples from patients we...

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Autores principales: Hellferscee, Orienka, Treurnicht, Florette K., Tempia, Stefano, Variava, Ebrahim, Dawood, Halima, Kahn, Kathleen, Cohen, Adam L., Pretorius, Marthi, Cohen, Cheryl, Madhi, Shabir A., Venter, Marietjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410726/
https://www.ncbi.nlm.nih.gov/pubmed/28122175
http://dx.doi.org/10.1111/irv.12444
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author Hellferscee, Orienka
Treurnicht, Florette K.
Tempia, Stefano
Variava, Ebrahim
Dawood, Halima
Kahn, Kathleen
Cohen, Adam L.
Pretorius, Marthi
Cohen, Cheryl
Madhi, Shabir A.
Venter, Marietjie
author_facet Hellferscee, Orienka
Treurnicht, Florette K.
Tempia, Stefano
Variava, Ebrahim
Dawood, Halima
Kahn, Kathleen
Cohen, Adam L.
Pretorius, Marthi
Cohen, Cheryl
Madhi, Shabir A.
Venter, Marietjie
author_sort Hellferscee, Orienka
collection PubMed
description BACKGROUND: Human enteroviruses (EV) have been associated with severe acute respiratory illness (SARI) in South Africa. OBJECTIVES: We aimed to describe the molecular epidemiology of EV serotypes among patients hospitalized with SARI during 2009‐2011. PATIENTS/METHODS: Study samples from patients were tested for the presence of enterovirus using a polymerase chain reaction assay. RESULTS: 8.2% (842/10 260) of SARI cases tested positive for enterovirus; 16% (7/45) were species EV‐A, 44% (20/45) EV‐B, 18% (8/45) EV‐C and 22% (10/45) EV‐D. Seventeen different EV serotypes were identified within EV‐A to EV‐D, of which EV‐D68 (22%; 10/45) and Echovirus 3 (11%; 5/45) were the most prevalent. CONCLUSIONS: EV‐D68 should be monitored in South Africa to assess the emergence of highly pathogenic strains.
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spelling pubmed-54107262017-05-03 Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011 Hellferscee, Orienka Treurnicht, Florette K. Tempia, Stefano Variava, Ebrahim Dawood, Halima Kahn, Kathleen Cohen, Adam L. Pretorius, Marthi Cohen, Cheryl Madhi, Shabir A. Venter, Marietjie Influenza Other Respir Viruses Original Articles BACKGROUND: Human enteroviruses (EV) have been associated with severe acute respiratory illness (SARI) in South Africa. OBJECTIVES: We aimed to describe the molecular epidemiology of EV serotypes among patients hospitalized with SARI during 2009‐2011. PATIENTS/METHODS: Study samples from patients were tested for the presence of enterovirus using a polymerase chain reaction assay. RESULTS: 8.2% (842/10 260) of SARI cases tested positive for enterovirus; 16% (7/45) were species EV‐A, 44% (20/45) EV‐B, 18% (8/45) EV‐C and 22% (10/45) EV‐D. Seventeen different EV serotypes were identified within EV‐A to EV‐D, of which EV‐D68 (22%; 10/45) and Echovirus 3 (11%; 5/45) were the most prevalent. CONCLUSIONS: EV‐D68 should be monitored in South Africa to assess the emergence of highly pathogenic strains. John Wiley and Sons Inc. 2017-02-26 2017-05 /pmc/articles/PMC5410726/ /pubmed/28122175 http://dx.doi.org/10.1111/irv.12444 Text en © 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Hellferscee, Orienka
Treurnicht, Florette K.
Tempia, Stefano
Variava, Ebrahim
Dawood, Halima
Kahn, Kathleen
Cohen, Adam L.
Pretorius, Marthi
Cohen, Cheryl
Madhi, Shabir A.
Venter, Marietjie
Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011
title Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011
title_full Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011
title_fullStr Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011
title_full_unstemmed Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011
title_short Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009–2011
title_sort enterovirus d68 and other enterovirus serotypes identified in south african patients with severe acute respiratory illness, 2009–2011
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410726/
https://www.ncbi.nlm.nih.gov/pubmed/28122175
http://dx.doi.org/10.1111/irv.12444
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