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Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward
Animal models of decision-making rely on an animal’s motivation to decide and its ability to detect differences among various alternatives. Food reinforcement, although commonly used, is associated with problematic confounds, especially satiety. Here, we examined the use of brain stimulation reward...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Society for Neuroscience
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411162/ https://www.ncbi.nlm.nih.gov/pubmed/28466068 http://dx.doi.org/10.1523/ENEURO.0015-17.2017 |
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author | McMurray, Matthew S. Conway, Sineadh M. Roitman, Jamie D. |
author_facet | McMurray, Matthew S. Conway, Sineadh M. Roitman, Jamie D. |
author_sort | McMurray, Matthew S. |
collection | PubMed |
description | Animal models of decision-making rely on an animal’s motivation to decide and its ability to detect differences among various alternatives. Food reinforcement, although commonly used, is associated with problematic confounds, especially satiety. Here, we examined the use of brain stimulation reward (BSR) as an alternative reinforcer in rodent models of decision-making and compared it with the effectiveness of sugar pellets. The discriminability of various BSR frequencies was compared to differing numbers of sugar pellets in separate free-choice tasks. We found that BSR was more discriminable and motivated greater task engagement and more consistent preference for the larger reward. We then investigated whether rats prefer BSR of varying frequencies over sugar pellets. We found that animals showed either a clear preference for sugar reward or no preference between reward modalities, depending on the frequency of the BSR alternative and the size of the sugar reward. Overall, these results suggest that BSR is an effective reinforcer in rodent decision-making tasks, removing food-related confounds and resulting in more accurate, consistent, and reliable metrics of choice. |
format | Online Article Text |
id | pubmed-5411162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Society for Neuroscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-54111622017-05-02 Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward McMurray, Matthew S. Conway, Sineadh M. Roitman, Jamie D. eNeuro New Research Animal models of decision-making rely on an animal’s motivation to decide and its ability to detect differences among various alternatives. Food reinforcement, although commonly used, is associated with problematic confounds, especially satiety. Here, we examined the use of brain stimulation reward (BSR) as an alternative reinforcer in rodent models of decision-making and compared it with the effectiveness of sugar pellets. The discriminability of various BSR frequencies was compared to differing numbers of sugar pellets in separate free-choice tasks. We found that BSR was more discriminable and motivated greater task engagement and more consistent preference for the larger reward. We then investigated whether rats prefer BSR of varying frequencies over sugar pellets. We found that animals showed either a clear preference for sugar reward or no preference between reward modalities, depending on the frequency of the BSR alternative and the size of the sugar reward. Overall, these results suggest that BSR is an effective reinforcer in rodent decision-making tasks, removing food-related confounds and resulting in more accurate, consistent, and reliable metrics of choice. Society for Neuroscience 2017-05-01 /pmc/articles/PMC5411162/ /pubmed/28466068 http://dx.doi.org/10.1523/ENEURO.0015-17.2017 Text en Copyright © 2017 McMurray et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | New Research McMurray, Matthew S. Conway, Sineadh M. Roitman, Jamie D. Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward |
title | Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward |
title_full | Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward |
title_fullStr | Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward |
title_full_unstemmed | Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward |
title_short | Brain Stimulation Reward Supports More Consistent and Accurate Rodent Decision-Making than Food Reward |
title_sort | brain stimulation reward supports more consistent and accurate rodent decision-making than food reward |
topic | New Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411162/ https://www.ncbi.nlm.nih.gov/pubmed/28466068 http://dx.doi.org/10.1523/ENEURO.0015-17.2017 |
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