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Mn(2+)-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy

Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn(2+)-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticle...

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Autores principales: Xi, Juqun, Da, Lanyue, Yang, Changshui, Chen, Rui, Gao, Lizeng, Fan, Lei, Han, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411169/
https://www.ncbi.nlm.nih.gov/pubmed/28479854
http://dx.doi.org/10.2147/IJN.S132270
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author Xi, Juqun
Da, Lanyue
Yang, Changshui
Chen, Rui
Gao, Lizeng
Fan, Lei
Han, Jie
author_facet Xi, Juqun
Da, Lanyue
Yang, Changshui
Chen, Rui
Gao, Lizeng
Fan, Lei
Han, Jie
author_sort Xi, Juqun
collection PubMed
description Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn(2+)-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn(2+) ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn(2+)-PDA@DOX/PLGA nanoparticles. In our system, Mn(2+)-PDA@DOX/PLGA nanoparticles could destroy tumors in a mouse model directly, by thermal energy deposition, and could also simulate the chemotherapy by thermal-responsive delivery of DOX to enhance tumor therapy. Furthermore, the coordination of Mn(2+) could afford the high magnetic resonance (MR) imaging capability with sensitivity to temperature and pH. The results demonstrated that Mn(2+)-PDA@ DOX/PLGA nanoparticles had a great potential as a smart theranostic agent due to their imaging and tumor-growth-inhibition properties.
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spelling pubmed-54111692017-05-05 Mn(2+)-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy Xi, Juqun Da, Lanyue Yang, Changshui Chen, Rui Gao, Lizeng Fan, Lei Han, Jie Int J Nanomedicine Original Research Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn(2+)-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles. Mn(2+) ions were then coordinated on the surfaces of PDA@DOX/PLGA to obtain Mn(2+)-PDA@DOX/PLGA nanoparticles. In our system, Mn(2+)-PDA@DOX/PLGA nanoparticles could destroy tumors in a mouse model directly, by thermal energy deposition, and could also simulate the chemotherapy by thermal-responsive delivery of DOX to enhance tumor therapy. Furthermore, the coordination of Mn(2+) could afford the high magnetic resonance (MR) imaging capability with sensitivity to temperature and pH. The results demonstrated that Mn(2+)-PDA@ DOX/PLGA nanoparticles had a great potential as a smart theranostic agent due to their imaging and tumor-growth-inhibition properties. Dove Medical Press 2017-04-24 /pmc/articles/PMC5411169/ /pubmed/28479854 http://dx.doi.org/10.2147/IJN.S132270 Text en © 2017 Xi et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Xi, Juqun
Da, Lanyue
Yang, Changshui
Chen, Rui
Gao, Lizeng
Fan, Lei
Han, Jie
Mn(2+)-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title Mn(2+)-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_full Mn(2+)-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_fullStr Mn(2+)-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_full_unstemmed Mn(2+)-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_short Mn(2+)-coordinated PDA@DOX/PLGA nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
title_sort mn(2+)-coordinated pda@dox/plga nanoparticles as a smart theranostic agent for synergistic chemo-photothermal tumor therapy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411169/
https://www.ncbi.nlm.nih.gov/pubmed/28479854
http://dx.doi.org/10.2147/IJN.S132270
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