The genetic relationship between epilepsy and hemiplegic migraine

Epilepsy and migraine are common diseases of the nervous system and share genetic and pathophysiological mechanisms. Familial hemiplegic migraine is an autosomal dominant disease. It is often used as a model of migraine. Four genes often contain one or more mutations in both epilepsy and hemiplegic...

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Autores principales: Huang, Yiqing, Xiao, Hai, Qin, Xingyue, Nong, Yuan, Zou, Donghua, Wu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411172/
https://www.ncbi.nlm.nih.gov/pubmed/28479855
http://dx.doi.org/10.2147/NDT.S132451
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author Huang, Yiqing
Xiao, Hai
Qin, Xingyue
Nong, Yuan
Zou, Donghua
Wu, Yuan
author_facet Huang, Yiqing
Xiao, Hai
Qin, Xingyue
Nong, Yuan
Zou, Donghua
Wu, Yuan
author_sort Huang, Yiqing
collection PubMed
description Epilepsy and migraine are common diseases of the nervous system and share genetic and pathophysiological mechanisms. Familial hemiplegic migraine is an autosomal dominant disease. It is often used as a model of migraine. Four genes often contain one or more mutations in both epilepsy and hemiplegic migraine patients (ie, CACNA1A, ATP1A2, SCN1A, and PRRT2). A better understanding of the shared genetics of epilepsy and hemiplegic migraine may reveal new strategic directions for research and treatment of both the disorders.
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spelling pubmed-54111722017-05-05 The genetic relationship between epilepsy and hemiplegic migraine Huang, Yiqing Xiao, Hai Qin, Xingyue Nong, Yuan Zou, Donghua Wu, Yuan Neuropsychiatr Dis Treat Review Epilepsy and migraine are common diseases of the nervous system and share genetic and pathophysiological mechanisms. Familial hemiplegic migraine is an autosomal dominant disease. It is often used as a model of migraine. Four genes often contain one or more mutations in both epilepsy and hemiplegic migraine patients (ie, CACNA1A, ATP1A2, SCN1A, and PRRT2). A better understanding of the shared genetics of epilepsy and hemiplegic migraine may reveal new strategic directions for research and treatment of both the disorders. Dove Medical Press 2017-04-24 /pmc/articles/PMC5411172/ /pubmed/28479855 http://dx.doi.org/10.2147/NDT.S132451 Text en © 2017 Huang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Huang, Yiqing
Xiao, Hai
Qin, Xingyue
Nong, Yuan
Zou, Donghua
Wu, Yuan
The genetic relationship between epilepsy and hemiplegic migraine
title The genetic relationship between epilepsy and hemiplegic migraine
title_full The genetic relationship between epilepsy and hemiplegic migraine
title_fullStr The genetic relationship between epilepsy and hemiplegic migraine
title_full_unstemmed The genetic relationship between epilepsy and hemiplegic migraine
title_short The genetic relationship between epilepsy and hemiplegic migraine
title_sort genetic relationship between epilepsy and hemiplegic migraine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411172/
https://www.ncbi.nlm.nih.gov/pubmed/28479855
http://dx.doi.org/10.2147/NDT.S132451
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