Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice

We determined risk of virologic failure (VF) in individuals initiating tenofovir/emtricitabine/efavirenz as single versus multiple tablet regimens (MTR). We found no significant difference in the risk of VF, though did observe a trend toward more VF and M184 V mutations among persons initiating MTR....

Descripción completa

Detalles Bibliográficos
Autores principales: Drozd, Daniel R., Saag, Michael S., Westfall, Andrew O., Mathews, William Chris, Haubrich, Richard, Boswell, Stephen L., Cole, Stephen R., Porter, Donna, Kitahata, Mari M., Juday, Timothy, Rosenblatt, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
4850
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411186/
https://www.ncbi.nlm.nih.gov/pubmed/28383402
http://dx.doi.org/10.1097/MD.0000000000006275
_version_ 1783232797550313472
author Drozd, Daniel R.
Saag, Michael S.
Westfall, Andrew O.
Mathews, William Chris
Haubrich, Richard
Boswell, Stephen L.
Cole, Stephen R.
Porter, Donna
Kitahata, Mari M.
Juday, Timothy
Rosenblatt, Lisa
author_facet Drozd, Daniel R.
Saag, Michael S.
Westfall, Andrew O.
Mathews, William Chris
Haubrich, Richard
Boswell, Stephen L.
Cole, Stephen R.
Porter, Donna
Kitahata, Mari M.
Juday, Timothy
Rosenblatt, Lisa
author_sort Drozd, Daniel R.
collection PubMed
description We determined risk of virologic failure (VF) in individuals initiating tenofovir/emtricitabine/efavirenz as single versus multiple tablet regimens (MTR). We found no significant difference in the risk of VF, though did observe a trend toward more VF and M184 V mutations among persons initiating MTR. Temporal trends in care may have confounded results.
format Online
Article
Text
id pubmed-5411186
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-54111862017-05-02 Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice Drozd, Daniel R. Saag, Michael S. Westfall, Andrew O. Mathews, William Chris Haubrich, Richard Boswell, Stephen L. Cole, Stephen R. Porter, Donna Kitahata, Mari M. Juday, Timothy Rosenblatt, Lisa Medicine (Baltimore) 4850 We determined risk of virologic failure (VF) in individuals initiating tenofovir/emtricitabine/efavirenz as single versus multiple tablet regimens (MTR). We found no significant difference in the risk of VF, though did observe a trend toward more VF and M184 V mutations among persons initiating MTR. Temporal trends in care may have confounded results. Wolters Kluwer Health 2017-04-07 /pmc/articles/PMC5411186/ /pubmed/28383402 http://dx.doi.org/10.1097/MD.0000000000006275 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 4850
Drozd, Daniel R.
Saag, Michael S.
Westfall, Andrew O.
Mathews, William Chris
Haubrich, Richard
Boswell, Stephen L.
Cole, Stephen R.
Porter, Donna
Kitahata, Mari M.
Juday, Timothy
Rosenblatt, Lisa
Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice
title Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice
title_full Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice
title_fullStr Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice
title_full_unstemmed Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice
title_short Comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical HIV practice
title_sort comparative effectiveness of single versus multiple tablet antiretroviral therapy regimens in clinical hiv practice
topic 4850
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411186/
https://www.ncbi.nlm.nih.gov/pubmed/28383402
http://dx.doi.org/10.1097/MD.0000000000006275
work_keys_str_mv AT drozddanielr comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT saagmichaels comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT westfallandrewo comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT mathewswilliamchris comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT haubrichrichard comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT boswellstephenl comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT colestephenr comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT porterdonna comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT kitahatamarim comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT judaytimothy comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice
AT rosenblattlisa comparativeeffectivenessofsingleversusmultipletabletantiretroviraltherapyregimensinclinicalhivpractice

Ejemplares similares