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Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study
BACKGROUND: Collagenous colitis (CC) is by definition a histological diagnosis. However, colonoscopy often reveals characteristic endoscopic findings. The aim of this study was to evaluate the frequency and type of endoscopic findings in patients diagnosed with CC in 4 participating centers. METHODS...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hellenic Society of Gastroenterology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411381/ https://www.ncbi.nlm.nih.gov/pubmed/28469361 http://dx.doi.org/10.20524/aog.2017.0131 |
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author | Koulaouzidis, Anastasios Yung, Diana E. Nemeth, Artur Sjöberg, Klas Giannakou, Andry Qureshi, Raheel Bartzis, Leonidas McNeill, Morna Johansson, Gabriele Wurm Lucendo, Alfredo J. Fineron, Paul Trimble, Ken C. Saeed, Athar Plevris, John N. Toth, Ervin |
author_facet | Koulaouzidis, Anastasios Yung, Diana E. Nemeth, Artur Sjöberg, Klas Giannakou, Andry Qureshi, Raheel Bartzis, Leonidas McNeill, Morna Johansson, Gabriele Wurm Lucendo, Alfredo J. Fineron, Paul Trimble, Ken C. Saeed, Athar Plevris, John N. Toth, Ervin |
author_sort | Koulaouzidis, Anastasios |
collection | PubMed |
description | BACKGROUND: Collagenous colitis (CC) is by definition a histological diagnosis. However, colonoscopy often reveals characteristic endoscopic findings. The aim of this study was to evaluate the frequency and type of endoscopic findings in patients diagnosed with CC in 4 participating centers. METHODS: This was a retrospective study; the databases of 2 university hospitals in Edinburgh (Scotland) and Malmö (Sweden), and 2 district general hospitals in Tomelloso (Spain) and Gateshead (England) were interrogated for patients diagnosed with CC between May 2008 and August 2013. Endoscopy reports and images were retrieved and reviewed; data on lesions, sedation, bowel preparation and endoscopist experience were abstracted. Categorical data are reported as mean±SD. Fischer’s exact, chi-square and t (unpaired) tests were used to compare datasets. A two-tailed P-value of <0.05 was considered statistically significant. RESULTS: 607 patients (149 male, mean age 66.9±12.25 years) were diagnosed with CC. A total of 108/607 (17.8%) patients had one or more suggestive endoscopy findings: i.e., mucosal erythema/edema, 91/607 (15%); linear colonic mucosal defects, 12/607 (2%); or mucosal scarring, 5/607 (0.82%). For colonic mucosa erythema, there was no difference in the odds of finding erythema with the use of different bowel preparation methods (P=0.997). For colonic mucosal defects there was some evidence (P=0.005) that patients colonoscoped by experienced endoscopists had 87% less odds of developing such defects. Moreover, there was evidence that analgesia reduced the odds of developing mucosal defects by 84%. CONCLUSION: A significant minority of patients with CC have endoscopic findings in colonoscopy. The description of such findings appears to be related to the endoscopist’s experience. |
format | Online Article Text |
id | pubmed-5411381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hellenic Society of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-54113812017-05-03 Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study Koulaouzidis, Anastasios Yung, Diana E. Nemeth, Artur Sjöberg, Klas Giannakou, Andry Qureshi, Raheel Bartzis, Leonidas McNeill, Morna Johansson, Gabriele Wurm Lucendo, Alfredo J. Fineron, Paul Trimble, Ken C. Saeed, Athar Plevris, John N. Toth, Ervin Ann Gastroenterol Original Article BACKGROUND: Collagenous colitis (CC) is by definition a histological diagnosis. However, colonoscopy often reveals characteristic endoscopic findings. The aim of this study was to evaluate the frequency and type of endoscopic findings in patients diagnosed with CC in 4 participating centers. METHODS: This was a retrospective study; the databases of 2 university hospitals in Edinburgh (Scotland) and Malmö (Sweden), and 2 district general hospitals in Tomelloso (Spain) and Gateshead (England) were interrogated for patients diagnosed with CC between May 2008 and August 2013. Endoscopy reports and images were retrieved and reviewed; data on lesions, sedation, bowel preparation and endoscopist experience were abstracted. Categorical data are reported as mean±SD. Fischer’s exact, chi-square and t (unpaired) tests were used to compare datasets. A two-tailed P-value of <0.05 was considered statistically significant. RESULTS: 607 patients (149 male, mean age 66.9±12.25 years) were diagnosed with CC. A total of 108/607 (17.8%) patients had one or more suggestive endoscopy findings: i.e., mucosal erythema/edema, 91/607 (15%); linear colonic mucosal defects, 12/607 (2%); or mucosal scarring, 5/607 (0.82%). For colonic mucosa erythema, there was no difference in the odds of finding erythema with the use of different bowel preparation methods (P=0.997). For colonic mucosal defects there was some evidence (P=0.005) that patients colonoscoped by experienced endoscopists had 87% less odds of developing such defects. Moreover, there was evidence that analgesia reduced the odds of developing mucosal defects by 84%. CONCLUSION: A significant minority of patients with CC have endoscopic findings in colonoscopy. The description of such findings appears to be related to the endoscopist’s experience. Hellenic Society of Gastroenterology 2017 2017-02-20 /pmc/articles/PMC5411381/ /pubmed/28469361 http://dx.doi.org/10.20524/aog.2017.0131 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Koulaouzidis, Anastasios Yung, Diana E. Nemeth, Artur Sjöberg, Klas Giannakou, Andry Qureshi, Raheel Bartzis, Leonidas McNeill, Morna Johansson, Gabriele Wurm Lucendo, Alfredo J. Fineron, Paul Trimble, Ken C. Saeed, Athar Plevris, John N. Toth, Ervin Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study |
title | Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study |
title_full | Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study |
title_fullStr | Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study |
title_full_unstemmed | Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study |
title_short | Macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study |
title_sort | macroscopic findings in collagenous colitis: a multi-center, retrospective, observational cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411381/ https://www.ncbi.nlm.nih.gov/pubmed/28469361 http://dx.doi.org/10.20524/aog.2017.0131 |
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