In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott–Aldrich Syndrome Protein-Deficient B Cells

Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency caused by mutations in the gene encoding the hematopoietic-specific WAS protein (WASp). WAS is frequently associated with autoimmunity, indicating a critical role of WASp in maintenance of tolerance. The role of B cells in the induction of...

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Detalles Bibliográficos
Autores principales: Castiello, Maria Carmina, Pala, Francesca, Sereni, Lucia, Draghici, Elena, Inverso, Donato, Sauer, Aisha V., Schena, Francesca, Fontana, Elena, Radaelli, Enrico, Uva, Paolo, Cervantes-Luevano, Karla E., Benvenuti, Federica, Poliani, Pietro L., Iannacone, Matteo, Traggiai, Elisabetta, Villa, Anna, Bosticardo, Marita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411424/
https://www.ncbi.nlm.nih.gov/pubmed/28512459
http://dx.doi.org/10.3389/fimmu.2017.00490

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