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Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts
Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safe...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411484/ https://www.ncbi.nlm.nih.gov/pubmed/28425465 http://dx.doi.org/10.1038/ncomms15048 |
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author | Liew, Nicole Mazon Moya, Maria J. Wierzbicki, Claudia J. Hollinshead, Michael Dillon, Michael J. Thornton, Christopher R. Ellison, Amy Cable, Jo Fisher, Matthew C. Mostowy, Serge |
author_facet | Liew, Nicole Mazon Moya, Maria J. Wierzbicki, Claudia J. Hollinshead, Michael Dillon, Michael J. Thornton, Christopher R. Ellison, Amy Cable, Jo Fisher, Matthew C. Mostowy, Serge |
author_sort | Liew, Nicole |
collection | PubMed |
description | Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurity. Here we extend our knowledge on the host range of the chytrid Batrachochytrium dendrobatidis by demonstrating infection of a non-amphibian vertebrate host, the zebrafish. We observe dose-dependent mortality and show that chytrid can infect and proliferate on zebrafish tissue. We also show that infection phenotypes (fin erosion, cell apoptosis and muscle degeneration) are direct symptoms of infection. Successful infection is dependent on disrupting the zebrafish microbiome, highlighting that, as is widely found in amphibians, commensal bacteria confer protection against this pathogen. Collectively, our findings greatly expand the limited tool kit available to study pathogenesis and host response to chytrid infection. |
format | Online Article Text |
id | pubmed-5411484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-54114842017-07-11 Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts Liew, Nicole Mazon Moya, Maria J. Wierzbicki, Claudia J. Hollinshead, Michael Dillon, Michael J. Thornton, Christopher R. Ellison, Amy Cable, Jo Fisher, Matthew C. Mostowy, Serge Nat Commun Article Aquatic chytrid fungi threaten amphibian biodiversity worldwide owing to their ability to rapidly expand their geographical distributions and to infect a wide range of hosts. Combating this risk requires an understanding of chytrid host range to identify potential reservoirs of infection and to safeguard uninfected regions through enhanced biosecurity. Here we extend our knowledge on the host range of the chytrid Batrachochytrium dendrobatidis by demonstrating infection of a non-amphibian vertebrate host, the zebrafish. We observe dose-dependent mortality and show that chytrid can infect and proliferate on zebrafish tissue. We also show that infection phenotypes (fin erosion, cell apoptosis and muscle degeneration) are direct symptoms of infection. Successful infection is dependent on disrupting the zebrafish microbiome, highlighting that, as is widely found in amphibians, commensal bacteria confer protection against this pathogen. Collectively, our findings greatly expand the limited tool kit available to study pathogenesis and host response to chytrid infection. Nature Publishing Group 2017-04-20 /pmc/articles/PMC5411484/ /pubmed/28425465 http://dx.doi.org/10.1038/ncomms15048 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liew, Nicole Mazon Moya, Maria J. Wierzbicki, Claudia J. Hollinshead, Michael Dillon, Michael J. Thornton, Christopher R. Ellison, Amy Cable, Jo Fisher, Matthew C. Mostowy, Serge Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts |
title | Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts |
title_full | Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts |
title_fullStr | Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts |
title_full_unstemmed | Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts |
title_short | Chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts |
title_sort | chytrid fungus infection in zebrafish demonstrates that the pathogen can parasitize non-amphibian vertebrate hosts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411484/ https://www.ncbi.nlm.nih.gov/pubmed/28425465 http://dx.doi.org/10.1038/ncomms15048 |
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