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A Strategy for Cultivation of Retargeted Oncolytic Herpes Simplex Viruses in Non-cancer Cells
The oncolytic herpes simplex virus (HSV) that has been approved for clinical practice and those HSVs in clinical trials are attenuated viruses, often with the neurovirulence gene γ(1)34.5 and additional genes deleted. One strategy to engineer nonattenuated oncolytic HSVs consists of retargeting the...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411604/ https://www.ncbi.nlm.nih.gov/pubmed/28250120 http://dx.doi.org/10.1128/JVI.00067-17 |