Immunization with DNA Plasmids Coding for Crimean-Congo Hemorrhagic Fever Virus Capsid and Envelope Proteins and/or Virus-Like Particles Induces Protection and Survival in Challenged Mice

Crimean-Congo hemorrhagic fever virus (CCHFV) is a bunyavirus causing severe hemorrhagic fever disease in humans, with high mortality rates. The requirement of a high-containment laboratory and the lack of an animal model hampered the study of the immune response and protection of vaccine candidates...

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Detalles Bibliográficos
Autores principales: Hinkula, Jorma, Devignot, Stéphanie, Åkerström, Sara, Karlberg, Helen, Wattrang, Eva, Bereczky, Sándor, Mousavi-Jazi, Mehrdad, Risinger, Christian, Lindegren, Gunnel, Vernersson, Caroline, Paweska, Janusz, van Vuren, Petrus Jansen, Blixt, Ola, Brun, Alejandro, Weber, Friedemann, Mirazimi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411611/
https://www.ncbi.nlm.nih.gov/pubmed/28250124
http://dx.doi.org/10.1128/JVI.02076-16

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