Pioneering EBF2 remodels the brown fat chromatin landscape

In this issue of Genes & Development, Shapira and colleagues (pp. 660–673) outline mechanisms by which the brown fat transcription factor early B-cell factor 2 (EBF2) selectively activates brown lineage-specific gene expression. The investigators show that EBF2 interacts with and recruits a tiss...

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Detalles Bibliográficos
Autores principales: Wang, Jiexin, Tontonoz, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411703/
https://www.ncbi.nlm.nih.gov/pubmed/28446594
http://dx.doi.org/10.1101/gad.299644.117
Descripción
Sumario:In this issue of Genes & Development, Shapira and colleagues (pp. 660–673) outline mechanisms by which the brown fat transcription factor early B-cell factor 2 (EBF2) selectively activates brown lineage-specific gene expression. The investigators show that EBF2 interacts with and recruits a tissue-specific BAF chromatin remodeling complex to brown fat gene enhancers, thereby regulating chromatin accessibility. Their findings provide important insight into epigenetic regulation of adipocyte fate and thermogenic gene expression.

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