Pioneering EBF2 remodels the brown fat chromatin landscape

In this issue of Genes & Development, Shapira and colleagues (pp. 660–673) outline mechanisms by which the brown fat transcription factor early B-cell factor 2 (EBF2) selectively activates brown lineage-specific gene expression. The investigators show that EBF2 interacts with and recruits a tiss...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jiexin, Tontonoz, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411703/
https://www.ncbi.nlm.nih.gov/pubmed/28446594
http://dx.doi.org/10.1101/gad.299644.117
_version_ 1783232850115428352
author Wang, Jiexin
Tontonoz, Peter
author_facet Wang, Jiexin
Tontonoz, Peter
author_sort Wang, Jiexin
collection PubMed
description In this issue of Genes & Development, Shapira and colleagues (pp. 660–673) outline mechanisms by which the brown fat transcription factor early B-cell factor 2 (EBF2) selectively activates brown lineage-specific gene expression. The investigators show that EBF2 interacts with and recruits a tissue-specific BAF chromatin remodeling complex to brown fat gene enhancers, thereby regulating chromatin accessibility. Their findings provide important insight into epigenetic regulation of adipocyte fate and thermogenic gene expression.
format Online
Article
Text
id pubmed-5411703
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-54117032017-10-01 Pioneering EBF2 remodels the brown fat chromatin landscape Wang, Jiexin Tontonoz, Peter Genes Dev Outlook In this issue of Genes & Development, Shapira and colleagues (pp. 660–673) outline mechanisms by which the brown fat transcription factor early B-cell factor 2 (EBF2) selectively activates brown lineage-specific gene expression. The investigators show that EBF2 interacts with and recruits a tissue-specific BAF chromatin remodeling complex to brown fat gene enhancers, thereby regulating chromatin accessibility. Their findings provide important insight into epigenetic regulation of adipocyte fate and thermogenic gene expression. Cold Spring Harbor Laboratory Press 2017-04-01 /pmc/articles/PMC5411703/ /pubmed/28446594 http://dx.doi.org/10.1101/gad.299644.117 Text en © 2017 Wang and Tontonoz; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Outlook
Wang, Jiexin
Tontonoz, Peter
Pioneering EBF2 remodels the brown fat chromatin landscape
title Pioneering EBF2 remodels the brown fat chromatin landscape
title_full Pioneering EBF2 remodels the brown fat chromatin landscape
title_fullStr Pioneering EBF2 remodels the brown fat chromatin landscape
title_full_unstemmed Pioneering EBF2 remodels the brown fat chromatin landscape
title_short Pioneering EBF2 remodels the brown fat chromatin landscape
title_sort pioneering ebf2 remodels the brown fat chromatin landscape
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411703/
https://www.ncbi.nlm.nih.gov/pubmed/28446594
http://dx.doi.org/10.1101/gad.299644.117
work_keys_str_mv AT wangjiexin pioneeringebf2remodelsthebrownfatchromatinlandscape
AT tontonozpeter pioneeringebf2remodelsthebrownfatchromatinlandscape

Ejemplares similares