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Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons

Telomeres have been studied extensively in peripheral tissues, but their relevance in the nervous system remains poorly understood. Here, we examine the roles of telomeres at distinct stages of murine brain development by using lineage-specific genetic ablation of TRF2, an essential component of the...

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Detalles Bibliográficos
Autores principales: Lobanova, Anastasia, She, Robert, Pieraut, Simon, Clapp, Charlie, Maximov, Anton, Denchi, Eros Lazzerini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411705/
https://www.ncbi.nlm.nih.gov/pubmed/28428263
http://dx.doi.org/10.1101/gad.295402.116