INHIBITION OF PACLITAXEL AGAINST NEUROGLIOMA CELLS U251 GROWTH AND ITS MECHANISM

BACKGROUND: Glioma is the most common primary tumor of the central nervous system, and accounted for about 70% of primary tumors. MATERIALS AND METHODS: In the study, antitumour activity and mechanism of paclitaxel was investigated. Different concentrations of paclitaxel (200, 300, 400 μmol/L) was t...

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Detalles Bibliográficos
Autores principales: Xin, ShiMeng, Yu, Fang, Yang, ChunYan, Hao, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: African Traditional Herbal Medicine Supporters Initiative (ATHMSI) 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411869/
https://www.ncbi.nlm.nih.gov/pubmed/28480395
http://dx.doi.org/10.21010/ajtcam.v14i1.19
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author Xin, ShiMeng
Yu, Fang
Yang, ChunYan
Hao, Xia
author_facet Xin, ShiMeng
Yu, Fang
Yang, ChunYan
Hao, Xia
author_sort Xin, ShiMeng
collection PubMed
description BACKGROUND: Glioma is the most common primary tumor of the central nervous system, and accounted for about 70% of primary tumors. MATERIALS AND METHODS: In the study, antitumour activity and mechanism of paclitaxel was investigated. Different concentrations of paclitaxel (200, 300, 400 μmol/L) was treated in neuroglioma cellsU251. RESULTS: Paclitaxel significantly inhibited neuroglioma cells growth, and promoted its apoptosis. Paclitaxel can block tumour cells in the G2/M phase. In addition, apoptosis-related genes caspase-3 and bax expressions were increased after paclitaxel treatment. CONCLUSION: Our work indicated that paclitaxel displayed strong anti-tumour activity.
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spelling pubmed-54118692017-06-05 INHIBITION OF PACLITAXEL AGAINST NEUROGLIOMA CELLS U251 GROWTH AND ITS MECHANISM Xin, ShiMeng Yu, Fang Yang, ChunYan Hao, Xia Afr J Tradit Complement Altern Med Article BACKGROUND: Glioma is the most common primary tumor of the central nervous system, and accounted for about 70% of primary tumors. MATERIALS AND METHODS: In the study, antitumour activity and mechanism of paclitaxel was investigated. Different concentrations of paclitaxel (200, 300, 400 μmol/L) was treated in neuroglioma cellsU251. RESULTS: Paclitaxel significantly inhibited neuroglioma cells growth, and promoted its apoptosis. Paclitaxel can block tumour cells in the G2/M phase. In addition, apoptosis-related genes caspase-3 and bax expressions were increased after paclitaxel treatment. CONCLUSION: Our work indicated that paclitaxel displayed strong anti-tumour activity. African Traditional Herbal Medicine Supporters Initiative (ATHMSI) 2016-11-23 /pmc/articles/PMC5411869/ /pubmed/28480395 http://dx.doi.org/10.21010/ajtcam.v14i1.19 Text en Copyright: © 2017 Afr. J. Traditional Complementary and Alternative Medicines http://creativecommons.org/licenses/CC-BY/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
spellingShingle Article
Xin, ShiMeng
Yu, Fang
Yang, ChunYan
Hao, Xia
INHIBITION OF PACLITAXEL AGAINST NEUROGLIOMA CELLS U251 GROWTH AND ITS MECHANISM
title INHIBITION OF PACLITAXEL AGAINST NEUROGLIOMA CELLS U251 GROWTH AND ITS MECHANISM
title_full INHIBITION OF PACLITAXEL AGAINST NEUROGLIOMA CELLS U251 GROWTH AND ITS MECHANISM
title_fullStr INHIBITION OF PACLITAXEL AGAINST NEUROGLIOMA CELLS U251 GROWTH AND ITS MECHANISM
title_full_unstemmed INHIBITION OF PACLITAXEL AGAINST NEUROGLIOMA CELLS U251 GROWTH AND ITS MECHANISM
title_short INHIBITION OF PACLITAXEL AGAINST NEUROGLIOMA CELLS U251 GROWTH AND ITS MECHANISM
title_sort inhibition of paclitaxel against neuroglioma cells u251 growth and its mechanism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411869/
https://www.ncbi.nlm.nih.gov/pubmed/28480395
http://dx.doi.org/10.21010/ajtcam.v14i1.19
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AT yangchunyan inhibitionofpaclitaxelagainstneurogliomacellsu251growthanditsmechanism
AT haoxia inhibitionofpaclitaxelagainstneurogliomacellsu251growthanditsmechanism

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