Role of circulating microRNAs in liver diseases

MicroRNAs (miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into the circulation and circulating miRNAs emerged as a new class of biomarkers for various diseases. In this review we summari...

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Autores principales: Loosen, Sven H, Schueller, Florian, Trautwein, Christian, Roy, Sanchari, Roderburg, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411953/
https://www.ncbi.nlm.nih.gov/pubmed/28515844
http://dx.doi.org/10.4254/wjh.v9.i12.586
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author Loosen, Sven H
Schueller, Florian
Trautwein, Christian
Roy, Sanchari
Roderburg, Christoph
author_facet Loosen, Sven H
Schueller, Florian
Trautwein, Christian
Roy, Sanchari
Roderburg, Christoph
author_sort Loosen, Sven H
collection PubMed
description MicroRNAs (miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into the circulation and circulating miRNAs emerged as a new class of biomarkers for various diseases. In this review we summarize available data on the role of circulating miRNAs in the context of acute and chronic liver diseases including hepatocellular and cholangiocellular carcinoma. Data from animal models are compared to human data and current challenges in the field of miRNAs research are discussed.
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spelling pubmed-54119532017-05-17 Role of circulating microRNAs in liver diseases Loosen, Sven H Schueller, Florian Trautwein, Christian Roy, Sanchari Roderburg, Christoph World J Hepatol Minireviews MicroRNAs (miRNAs) are small RNAs regulate gene expression by inhibiting the turnover of their target mRNAs. In the last years, it became apparent that miRNAs are released into the circulation and circulating miRNAs emerged as a new class of biomarkers for various diseases. In this review we summarize available data on the role of circulating miRNAs in the context of acute and chronic liver diseases including hepatocellular and cholangiocellular carcinoma. Data from animal models are compared to human data and current challenges in the field of miRNAs research are discussed. Baishideng Publishing Group Inc 2017-04-28 2017-04-28 /pmc/articles/PMC5411953/ /pubmed/28515844 http://dx.doi.org/10.4254/wjh.v9.i12.586 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Minireviews
Loosen, Sven H
Schueller, Florian
Trautwein, Christian
Roy, Sanchari
Roderburg, Christoph
Role of circulating microRNAs in liver diseases
title Role of circulating microRNAs in liver diseases
title_full Role of circulating microRNAs in liver diseases
title_fullStr Role of circulating microRNAs in liver diseases
title_full_unstemmed Role of circulating microRNAs in liver diseases
title_short Role of circulating microRNAs in liver diseases
title_sort role of circulating micrornas in liver diseases
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411953/
https://www.ncbi.nlm.nih.gov/pubmed/28515844
http://dx.doi.org/10.4254/wjh.v9.i12.586
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