Asymmetrical barcode adapter-assisted recovery of duplicate reads and error correction strategy to detect rare mutations in circulating tumor DNA

Deep sequencing is required for the highly sensitive detection of rare variants in circulating tumor DNA (ctDNA). However, there remains a challenge for improved sensitivity and specificity. Maximum-depth sequencing is crucial to detect minority mutations that contribute to cancer progression. The a...

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Detalles Bibliográficos
Autores principales: Ahn, Jinwoo, Hwang, Byungjin, Young Kim, Ha, Jang, Hoon, Kim, Hwang-Phill, Han, Sae-Won, Kim, Tae-You, Hyun Lee, Ji, Bang, Duhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411960/
https://www.ncbi.nlm.nih.gov/pubmed/28462938
http://dx.doi.org/10.1038/srep46678

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