Cargando…
The cysteine-rich domain of TET2 binds preferentially to mono- and dimethylated histone H3K36
Missense mutations in Ten-eleven translocation 2 (TET2) gene are frequently found in leukaemia patients. Although mutations span the entire coding region, they tend to cluster in the C-terminal enzymatic domain and a cysteine-rich (CR) domain of unknown function. Herein, we found the CR domain binds...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412023/ https://www.ncbi.nlm.nih.gov/pubmed/28130413 http://dx.doi.org/10.1093/jb/mvx004 |