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Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge
BACKGROUND: To explore the features of ductoscopic appearance that may be diagnostic in patients with pathologic nipple discharge (PND) and to discuss the diagnostic criteria for intraductal tumors. METHODS: We reviewed 247 patients with PND but without a palpable mass who were evaluated using eithe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412041/ https://www.ncbi.nlm.nih.gov/pubmed/28464874 http://dx.doi.org/10.1186/s12885-017-3288-3 |
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author | Han, Ye Li, Jianyi Han, Sijia Jia, Shi Zhang, Yang Zhang, Wenhai |
author_facet | Han, Ye Li, Jianyi Han, Sijia Jia, Shi Zhang, Yang Zhang, Wenhai |
author_sort | Han, Ye |
collection | PubMed |
description | BACKGROUND: To explore the features of ductoscopic appearance that may be diagnostic in patients with pathologic nipple discharge (PND) and to discuss the diagnostic criteria for intraductal tumors. METHODS: We reviewed 247 patients with PND but without a palpable mass who were evaluated using either surgical biopsy or excision. Data concerning patient age, duration of discharge, discharge color, and the details of endoscopic appearance were analyzed according to the pathological results. RESULTS: The postoperative diagnosis in 61 patients (24.70%) was a nonmass lesion, and 186 patients (76.52%) had an intraductal tumor. Among those with intraductal lesions, 10 patients (4.05%) had a malignant tumor, including 4 (1.62%) with ductal carcinoma in situ and 6 (2.43%) with invasive ductal carcinoma. On univariate analysis, patients of older age with spontaneous and bloody discharge were more likely to suffer from intraductal lesions. On logistic regression analysis, bloody nipple discharge, morphology, and a broad lesion base revealed by ductoscopy showed a statistically significant correlation with malignancy (p = 0.001, p < 0.001, p = 0.022, respectively). CONCLUSIONS: Both clinical features and endoscopic appearance are significant for the precise diagnosis of an intraductal lesion seen on ductoscopy. The endoscopic features of bloody discharge, morphology, and a broad lesion base are independent risk factors for malignancy and represent new criteria for the diagnosis of patients with PND. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-017-3288-3) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5412041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54120412017-05-03 Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge Han, Ye Li, Jianyi Han, Sijia Jia, Shi Zhang, Yang Zhang, Wenhai BMC Cancer Research Article BACKGROUND: To explore the features of ductoscopic appearance that may be diagnostic in patients with pathologic nipple discharge (PND) and to discuss the diagnostic criteria for intraductal tumors. METHODS: We reviewed 247 patients with PND but without a palpable mass who were evaluated using either surgical biopsy or excision. Data concerning patient age, duration of discharge, discharge color, and the details of endoscopic appearance were analyzed according to the pathological results. RESULTS: The postoperative diagnosis in 61 patients (24.70%) was a nonmass lesion, and 186 patients (76.52%) had an intraductal tumor. Among those with intraductal lesions, 10 patients (4.05%) had a malignant tumor, including 4 (1.62%) with ductal carcinoma in situ and 6 (2.43%) with invasive ductal carcinoma. On univariate analysis, patients of older age with spontaneous and bloody discharge were more likely to suffer from intraductal lesions. On logistic regression analysis, bloody nipple discharge, morphology, and a broad lesion base revealed by ductoscopy showed a statistically significant correlation with malignancy (p = 0.001, p < 0.001, p = 0.022, respectively). CONCLUSIONS: Both clinical features and endoscopic appearance are significant for the precise diagnosis of an intraductal lesion seen on ductoscopy. The endoscopic features of bloody discharge, morphology, and a broad lesion base are independent risk factors for malignancy and represent new criteria for the diagnosis of patients with PND. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-017-3288-3) contains supplementary material, which is available to authorized users. BioMed Central 2017-05-02 /pmc/articles/PMC5412041/ /pubmed/28464874 http://dx.doi.org/10.1186/s12885-017-3288-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Han, Ye Li, Jianyi Han, Sijia Jia, Shi Zhang, Yang Zhang, Wenhai Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge |
title | Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge |
title_full | Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge |
title_fullStr | Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge |
title_full_unstemmed | Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge |
title_short | Diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge |
title_sort | diagnostic value of endoscopic appearance during ductoscopy in patients with pathological nipple discharge |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412041/ https://www.ncbi.nlm.nih.gov/pubmed/28464874 http://dx.doi.org/10.1186/s12885-017-3288-3 |
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