Apoptosis in ischemic heart disease

Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure. Finding a sensitive apoptotic marker that would help in prognostic stratification of pati...

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Detalles Bibliográficos
Autores principales: Teringova, Elena, Tousek, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412049/
https://www.ncbi.nlm.nih.gov/pubmed/28460644
http://dx.doi.org/10.1186/s12967-017-1191-y
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author Teringova, Elena
Tousek, Petr
author_facet Teringova, Elena
Tousek, Petr
author_sort Teringova, Elena
collection PubMed
description Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure. Finding a sensitive apoptotic marker that would help in prognostic stratification of patients after acute myocardial infarction and offer new therapeutic strategies is thus of a great importance. Several studies suggest that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) represents a very promising marker of prognosis in patients with acute myocardial infarction. This review article provides an overview of current knowledge on the role of apoptosis in ischemic heart disease and highlights potentially beneficial apoptotic markers in clinical practice.
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spelling pubmed-54120492017-05-03 Apoptosis in ischemic heart disease Teringova, Elena Tousek, Petr J Transl Med Review Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure. Finding a sensitive apoptotic marker that would help in prognostic stratification of patients after acute myocardial infarction and offer new therapeutic strategies is thus of a great importance. Several studies suggest that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) represents a very promising marker of prognosis in patients with acute myocardial infarction. This review article provides an overview of current knowledge on the role of apoptosis in ischemic heart disease and highlights potentially beneficial apoptotic markers in clinical practice. BioMed Central 2017-05-01 /pmc/articles/PMC5412049/ /pubmed/28460644 http://dx.doi.org/10.1186/s12967-017-1191-y Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Teringova, Elena
Tousek, Petr
Apoptosis in ischemic heart disease
title Apoptosis in ischemic heart disease
title_full Apoptosis in ischemic heart disease
title_fullStr Apoptosis in ischemic heart disease
title_full_unstemmed Apoptosis in ischemic heart disease
title_short Apoptosis in ischemic heart disease
title_sort apoptosis in ischemic heart disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412049/
https://www.ncbi.nlm.nih.gov/pubmed/28460644
http://dx.doi.org/10.1186/s12967-017-1191-y
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