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The biological function of the cellular prion protein: an update

The misfolding of the cellular prion protein (PrP(C)) causes fatal neurodegenerative diseases. Yet PrP(C) is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrP(C) in mice results in well-defined structural and function...

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Detalles Bibliográficos
Autores principales:	Wulf, Marie-Angela, Senatore, Assunta, Aguzzi, Adriano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412054/ https://www.ncbi.nlm.nih.gov/pubmed/28464931 http://dx.doi.org/10.1186/s12915-017-0375-5

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