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Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders

Objective. The aim of this study was to investigate the cognitive function characteristics of Parkinson's disease (PD) with sleep disorders. Methods. Consecutive patients with PD (n = 96), patients with primary sleep disorders (n = 76), and healthy control subjects (n = 66) were assessed. The p...

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Autores principales: Huang, Jing, Zhuo, Wenyan, Zhang, Yuhu, Sun, Hongchun, Chen, Huan, Zhu, Peipei, Pan, Xiaobo, Yang, Jianhao, Wang, Lijuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412171/
https://www.ncbi.nlm.nih.gov/pubmed/28484661
http://dx.doi.org/10.1155/2017/4267353
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author Huang, Jing
Zhuo, Wenyan
Zhang, Yuhu
Sun, Hongchun
Chen, Huan
Zhu, Peipei
Pan, Xiaobo
Yang, Jianhao
Wang, Lijuan
author_facet Huang, Jing
Zhuo, Wenyan
Zhang, Yuhu
Sun, Hongchun
Chen, Huan
Zhu, Peipei
Pan, Xiaobo
Yang, Jianhao
Wang, Lijuan
author_sort Huang, Jing
collection PubMed
description Objective. The aim of this study was to investigate the cognitive function characteristics of Parkinson's disease (PD) with sleep disorders. Methods. Consecutive patients with PD (n = 96), patients with primary sleep disorders (n = 76), and healthy control subjects (n = 66) were assessed. The patients with PD were classified into sleep disorder (PD-SD) and non-sleep disorder (PD-NSD) groups. Results. Among 96 patients with PD, 69 were diagnosed with a sleep disorder. There were 38 sleep disorder cases, 31 RBD cases, and 27 NSD cases. On the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and MoCA subtests, patients in the PD-SD, primary sleep disorder, and PD-NSD groups exhibited lower scores than those in the control group. Moreover, the PD-SD patients exhibited more significant cognitive impairment than was observed in the primary sleep disorder patients. In the PD-SD subgroup, the attention scores on the MoCA and on MoCA subtests were lower in the PD with RBD group than in the PD with insomnia group. Conclusion. PD with sleep disorders may exacerbate cognitive dysfunction in patients. PD associated with different types of sleep disorders differentially affects cognitive functions, and patients with PD with RBD exhibited poorer cognitive function than was seen in patients with PD with insomnia.
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spelling pubmed-54121712017-05-08 Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders Huang, Jing Zhuo, Wenyan Zhang, Yuhu Sun, Hongchun Chen, Huan Zhu, Peipei Pan, Xiaobo Yang, Jianhao Wang, Lijuan Parkinsons Dis Research Article Objective. The aim of this study was to investigate the cognitive function characteristics of Parkinson's disease (PD) with sleep disorders. Methods. Consecutive patients with PD (n = 96), patients with primary sleep disorders (n = 76), and healthy control subjects (n = 66) were assessed. The patients with PD were classified into sleep disorder (PD-SD) and non-sleep disorder (PD-NSD) groups. Results. Among 96 patients with PD, 69 were diagnosed with a sleep disorder. There were 38 sleep disorder cases, 31 RBD cases, and 27 NSD cases. On the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and MoCA subtests, patients in the PD-SD, primary sleep disorder, and PD-NSD groups exhibited lower scores than those in the control group. Moreover, the PD-SD patients exhibited more significant cognitive impairment than was observed in the primary sleep disorder patients. In the PD-SD subgroup, the attention scores on the MoCA and on MoCA subtests were lower in the PD with RBD group than in the PD with insomnia group. Conclusion. PD with sleep disorders may exacerbate cognitive dysfunction in patients. PD associated with different types of sleep disorders differentially affects cognitive functions, and patients with PD with RBD exhibited poorer cognitive function than was seen in patients with PD with insomnia. Hindawi 2017 2017-04-18 /pmc/articles/PMC5412171/ /pubmed/28484661 http://dx.doi.org/10.1155/2017/4267353 Text en Copyright © 2017 Jing Huang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Huang, Jing
Zhuo, Wenyan
Zhang, Yuhu
Sun, Hongchun
Chen, Huan
Zhu, Peipei
Pan, Xiaobo
Yang, Jianhao
Wang, Lijuan
Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders
title Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders
title_full Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders
title_fullStr Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders
title_full_unstemmed Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders
title_short Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders
title_sort cognitive function characteristics of parkinson's disease with sleep disorders
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412171/
https://www.ncbi.nlm.nih.gov/pubmed/28484661
http://dx.doi.org/10.1155/2017/4267353
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