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Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation
Prodigiosin is a red pigment produced by Serratia marcescens. Prodigiosin is regarded as a promising drug owing to its reported characteristics of possessing anti-microbial, anti-cancer, and immunosuppressive activity. A factorial design was applied to generate a set of 32 experimental combinations...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412256/ https://www.ncbi.nlm.nih.gov/pubmed/28491819 http://dx.doi.org/10.1016/j.btre.2017.04.001 |
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author | Elkenawy, Nora M. Yassin, Aymen S. Elhifnawy, Hala N. Amin, Magdy A. |
author_facet | Elkenawy, Nora M. Yassin, Aymen S. Elhifnawy, Hala N. Amin, Magdy A. |
author_sort | Elkenawy, Nora M. |
collection | PubMed |
description | Prodigiosin is a red pigment produced by Serratia marcescens. Prodigiosin is regarded as a promising drug owing to its reported characteristics of possessing anti-microbial, anti-cancer, and immunosuppressive activity. A factorial design was applied to generate a set of 32 experimental combinations to study the optimal conditions for pigment production using crude glycerol obtained from local biodiesel facility as carbon source for the growth of Serratia marcescens. The maximum production (870 unit/cell) was achieved at 22 °C, at pH 9 with the addition of 1% (w/v) peptone and 10(9) cell/ml inoculum size after 6 days of incubation. Gamma radiation at dose 200 Gy was capable of doubling the production of the pigment using the optimized conditions and manipulating production temperature. Our results indicate that we have designed an economic medium supporting enhanced Serratia marcescens MN5 prodigiosin production giving an added value for crude glycerol obtained from biodiesel industry. |
format | Online Article Text |
id | pubmed-5412256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-54122562017-05-10 Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation Elkenawy, Nora M. Yassin, Aymen S. Elhifnawy, Hala N. Amin, Magdy A. Biotechnol Rep (Amst) Article Prodigiosin is a red pigment produced by Serratia marcescens. Prodigiosin is regarded as a promising drug owing to its reported characteristics of possessing anti-microbial, anti-cancer, and immunosuppressive activity. A factorial design was applied to generate a set of 32 experimental combinations to study the optimal conditions for pigment production using crude glycerol obtained from local biodiesel facility as carbon source for the growth of Serratia marcescens. The maximum production (870 unit/cell) was achieved at 22 °C, at pH 9 with the addition of 1% (w/v) peptone and 10(9) cell/ml inoculum size after 6 days of incubation. Gamma radiation at dose 200 Gy was capable of doubling the production of the pigment using the optimized conditions and manipulating production temperature. Our results indicate that we have designed an economic medium supporting enhanced Serratia marcescens MN5 prodigiosin production giving an added value for crude glycerol obtained from biodiesel industry. Elsevier 2017-04-18 /pmc/articles/PMC5412256/ /pubmed/28491819 http://dx.doi.org/10.1016/j.btre.2017.04.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Elkenawy, Nora M. Yassin, Aymen S. Elhifnawy, Hala N. Amin, Magdy A. Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation |
title | Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation |
title_full | Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation |
title_fullStr | Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation |
title_full_unstemmed | Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation |
title_short | Optimization of prodigiosin production by Serratia marcescens using crude glycerol and enhancing production using gamma radiation |
title_sort | optimization of prodigiosin production by serratia marcescens using crude glycerol and enhancing production using gamma radiation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412256/ https://www.ncbi.nlm.nih.gov/pubmed/28491819 http://dx.doi.org/10.1016/j.btre.2017.04.001 |
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