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CRISPR-Cas9 Mediated Gene-Silencing of the Mutant Huntingtin Gene in an In Vitro Model of Huntington’s Disease

Huntington’s disease (HD) is a fatal neurodegenerative genetic disease characterized by a loss of neurons in the striatum. It is caused by a mutation in the Huntingtin gene (HTT) that codes for the protein huntingtin (HTT). The mutant Huntingtin gene (mHTT) contains extra poly-glutamine (CAG) repeat...

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Detalles Bibliográficos
Autores principales:	Kolli, Nivya, Lu, Ming, Maiti, Panchanan, Rossignol, Julien, Dunbar, Gary L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412339/ https://www.ncbi.nlm.nih.gov/pubmed/28368337 http://dx.doi.org/10.3390/ijms18040754

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