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Efficacy and Safety of SGLT2 Inhibitors in Reducing Glycated Hemoglobin and Weight in Emirati Patients With Type 2 Diabetes

BACKGROUND: SGLT2 inhibitors are a new class of drugs that act by inhibiting glucose reabsorption in the proximal renal tubules. Many trials have demonstrated their effectiveness in reducing glycated hemoglobin (HbA1c) and weight, but they have never been examined in Arab or Emirati populations. MET...

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Autores principales: Bashier, Alaaeldin, Khalifa, Azza Abdulaziz, Rashid, Fauzia, Abdelgadir, Elamin Ibrahim, Al Qaysi, Amina Adil, Ali, Razan, Eltinay, Ahmed, Nafach, Jalal, Alsayyah, Fatima, Alawadi, Fatheya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412523/
https://www.ncbi.nlm.nih.gov/pubmed/28496550
http://dx.doi.org/10.14740/jocmr2976w
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author Bashier, Alaaeldin
Khalifa, Azza Abdulaziz
Rashid, Fauzia
Abdelgadir, Elamin Ibrahim
Al Qaysi, Amina Adil
Ali, Razan
Eltinay, Ahmed
Nafach, Jalal
Alsayyah, Fatima
Alawadi, Fatheya
author_facet Bashier, Alaaeldin
Khalifa, Azza Abdulaziz
Rashid, Fauzia
Abdelgadir, Elamin Ibrahim
Al Qaysi, Amina Adil
Ali, Razan
Eltinay, Ahmed
Nafach, Jalal
Alsayyah, Fatima
Alawadi, Fatheya
author_sort Bashier, Alaaeldin
collection PubMed
description BACKGROUND: SGLT2 inhibitors are a new class of drugs that act by inhibiting glucose reabsorption in the proximal renal tubules. Many trials have demonstrated their effectiveness in reducing glycated hemoglobin (HbA1c) and weight, but they have never been examined in Arab or Emirati populations. METHODS: We assessed the efficacy of SGLT2 inhibitors in reducing HbA1c and weight in our population and specifically in an Emirati cohort. We also assessed the effect on fasting blood glucose, blood pressure, lipid profile, serum creatinine, and side effects. RESULTS: The total number of patients was 307. The baseline HbA1c in the Emirati cohort was 8.9±1.7%, which dropped significantly to 8±1.5% at 6 months (P = 0.0001). At 1 year, the mean HbA1c was 8±1.4%, which was significantly different from baseline (P = 0.0001). However, the change in mean HbA1c from 6 months (8±1.5%) to 1 year (8±1.4%) was not statistically significant (P = 0.88). A similar highly significant change was observed when comparing weights at baseline and 6 months in the Emirati population (85.7 ± 17.8 kg vs. 84 ± 17.2 kg, P = 0.0001). Total cholesterol dropped significantly at 6 months (P = 0.008), as did low-density lipoprotein (LDL) (P = 0.005). CONCLUSIONS: The use of SGLT2 inhibitors is associated with significant reductions in HbA1c and weight. Unlike all previous trials, the inhibitors significantly reduced total cholesterol and LDL. Larger trials are needed to reassess their effects on lipid parameters.
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spelling pubmed-54125232017-05-11 Efficacy and Safety of SGLT2 Inhibitors in Reducing Glycated Hemoglobin and Weight in Emirati Patients With Type 2 Diabetes Bashier, Alaaeldin Khalifa, Azza Abdulaziz Rashid, Fauzia Abdelgadir, Elamin Ibrahim Al Qaysi, Amina Adil Ali, Razan Eltinay, Ahmed Nafach, Jalal Alsayyah, Fatima Alawadi, Fatheya J Clin Med Res Original Article BACKGROUND: SGLT2 inhibitors are a new class of drugs that act by inhibiting glucose reabsorption in the proximal renal tubules. Many trials have demonstrated their effectiveness in reducing glycated hemoglobin (HbA1c) and weight, but they have never been examined in Arab or Emirati populations. METHODS: We assessed the efficacy of SGLT2 inhibitors in reducing HbA1c and weight in our population and specifically in an Emirati cohort. We also assessed the effect on fasting blood glucose, blood pressure, lipid profile, serum creatinine, and side effects. RESULTS: The total number of patients was 307. The baseline HbA1c in the Emirati cohort was 8.9±1.7%, which dropped significantly to 8±1.5% at 6 months (P = 0.0001). At 1 year, the mean HbA1c was 8±1.4%, which was significantly different from baseline (P = 0.0001). However, the change in mean HbA1c from 6 months (8±1.5%) to 1 year (8±1.4%) was not statistically significant (P = 0.88). A similar highly significant change was observed when comparing weights at baseline and 6 months in the Emirati population (85.7 ± 17.8 kg vs. 84 ± 17.2 kg, P = 0.0001). Total cholesterol dropped significantly at 6 months (P = 0.008), as did low-density lipoprotein (LDL) (P = 0.005). CONCLUSIONS: The use of SGLT2 inhibitors is associated with significant reductions in HbA1c and weight. Unlike all previous trials, the inhibitors significantly reduced total cholesterol and LDL. Larger trials are needed to reassess their effects on lipid parameters. Elmer Press 2017-06 2017-04-26 /pmc/articles/PMC5412523/ /pubmed/28496550 http://dx.doi.org/10.14740/jocmr2976w Text en Copyright 2017, Bashier et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bashier, Alaaeldin
Khalifa, Azza Abdulaziz
Rashid, Fauzia
Abdelgadir, Elamin Ibrahim
Al Qaysi, Amina Adil
Ali, Razan
Eltinay, Ahmed
Nafach, Jalal
Alsayyah, Fatima
Alawadi, Fatheya
Efficacy and Safety of SGLT2 Inhibitors in Reducing Glycated Hemoglobin and Weight in Emirati Patients With Type 2 Diabetes
title Efficacy and Safety of SGLT2 Inhibitors in Reducing Glycated Hemoglobin and Weight in Emirati Patients With Type 2 Diabetes
title_full Efficacy and Safety of SGLT2 Inhibitors in Reducing Glycated Hemoglobin and Weight in Emirati Patients With Type 2 Diabetes
title_fullStr Efficacy and Safety of SGLT2 Inhibitors in Reducing Glycated Hemoglobin and Weight in Emirati Patients With Type 2 Diabetes
title_full_unstemmed Efficacy and Safety of SGLT2 Inhibitors in Reducing Glycated Hemoglobin and Weight in Emirati Patients With Type 2 Diabetes
title_short Efficacy and Safety of SGLT2 Inhibitors in Reducing Glycated Hemoglobin and Weight in Emirati Patients With Type 2 Diabetes
title_sort efficacy and safety of sglt2 inhibitors in reducing glycated hemoglobin and weight in emirati patients with type 2 diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412523/
https://www.ncbi.nlm.nih.gov/pubmed/28496550
http://dx.doi.org/10.14740/jocmr2976w
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