The evolutionary origins of antagonistic neurotrophin signaling

A competitive balance between constructive and destructive developmental cues governs both the form and function of the vertebrate nervous system. In this issue, Foldi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607098) explore the evolutionary origins of these cues and report that in...

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Detalles Bibliográficos
Autores principales: Keeler, Austin B., Deppmann, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412573/
https://www.ncbi.nlm.nih.gov/pubmed/28411190
http://dx.doi.org/10.1083/jcb.201702115
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author Keeler, Austin B.
Deppmann, Christopher D.
author_facet Keeler, Austin B.
Deppmann, Christopher D.
author_sort Keeler, Austin B.
collection PubMed
description A competitive balance between constructive and destructive developmental cues governs both the form and function of the vertebrate nervous system. In this issue, Foldi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607098) explore the evolutionary origins of these cues and report that in Drosophila melanogaster pro- and mature neurotrophins are capable of inducing death and survival pathways, respectively, by binding Toll receptor family members, which then recruit distinct sets of effector proteins.
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spelling pubmed-54125732017-11-01 The evolutionary origins of antagonistic neurotrophin signaling Keeler, Austin B. Deppmann, Christopher D. J Cell Biol Commentary A competitive balance between constructive and destructive developmental cues governs both the form and function of the vertebrate nervous system. In this issue, Foldi et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607098) explore the evolutionary origins of these cues and report that in Drosophila melanogaster pro- and mature neurotrophins are capable of inducing death and survival pathways, respectively, by binding Toll receptor family members, which then recruit distinct sets of effector proteins. The Rockefeller University Press 2017-05-01 /pmc/articles/PMC5412573/ /pubmed/28411190 http://dx.doi.org/10.1083/jcb.201702115 Text en © 2017 Keeler and Deppmann http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Keeler, Austin B.
Deppmann, Christopher D.
The evolutionary origins of antagonistic neurotrophin signaling
title The evolutionary origins of antagonistic neurotrophin signaling
title_full The evolutionary origins of antagonistic neurotrophin signaling
title_fullStr The evolutionary origins of antagonistic neurotrophin signaling
title_full_unstemmed The evolutionary origins of antagonistic neurotrophin signaling
title_short The evolutionary origins of antagonistic neurotrophin signaling
title_sort evolutionary origins of antagonistic neurotrophin signaling
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412573/
https://www.ncbi.nlm.nih.gov/pubmed/28411190
http://dx.doi.org/10.1083/jcb.201702115
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