Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination

Neural stem cells or neuroblasts in the Drosophila melanogaster embryo delaminate as single cells from the embryonic epidermis to give rise to the nervous system. Using this accessible system to examine the molecular mechanisms of cell ingression at a high temporal and spatial resolution, in this is...

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Detalles Bibliográficos
Autores principales: Sidor, Clara, Röper, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412574/
https://www.ncbi.nlm.nih.gov/pubmed/28404642
http://dx.doi.org/10.1083/jcb.201702116
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author Sidor, Clara
Röper, Katja
author_facet Sidor, Clara
Röper, Katja
author_sort Sidor, Clara
collection PubMed
description Neural stem cells or neuroblasts in the Drosophila melanogaster embryo delaminate as single cells from the embryonic epidermis to give rise to the nervous system. Using this accessible system to examine the molecular mechanisms of cell ingression at a high temporal and spatial resolution, in this issue, Simões et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608038) reveal that myosin-driven anisotropic junction loss and apical constriction are the main drivers of this process.
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spelling pubmed-54125742017-11-01 Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination Sidor, Clara Röper, Katja J Cell Biol Commentary Neural stem cells or neuroblasts in the Drosophila melanogaster embryo delaminate as single cells from the embryonic epidermis to give rise to the nervous system. Using this accessible system to examine the molecular mechanisms of cell ingression at a high temporal and spatial resolution, in this issue, Simões et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608038) reveal that myosin-driven anisotropic junction loss and apical constriction are the main drivers of this process. The Rockefeller University Press 2017-05-01 /pmc/articles/PMC5412574/ /pubmed/28404642 http://dx.doi.org/10.1083/jcb.201702116 Text en © 2017 Crown copyright. The government of Australia, Canada, or the UK ("the Crown") owns the copyright interests of authors who are government employees. The Crown Copyright is not transferable. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Sidor, Clara
Röper, Katja
Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination
title Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination
title_full Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination
title_fullStr Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination
title_full_unstemmed Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination
title_short Squeezing out in a “tug of war”: The role of myosin in neural stem cell delamination
title_sort squeezing out in a “tug of war”: the role of myosin in neural stem cell delamination
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412574/
https://www.ncbi.nlm.nih.gov/pubmed/28404642
http://dx.doi.org/10.1083/jcb.201702116
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