A mild catalytic system for radical conjugate addition of nitrogen heterocycles

The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to...

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Detalles Bibliográficos
Autores principales: Aycock, R. A., Wang, H., Jui, N. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412691/
https://www.ncbi.nlm.nih.gov/pubmed/28507687
http://dx.doi.org/10.1039/c7sc00243b
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author Aycock, R. A.
Wang, H.
Jui, N. T.
author_facet Aycock, R. A.
Wang, H.
Jui, N. T.
author_sort Aycock, R. A.
collection PubMed
description The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.
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spelling pubmed-54126912017-05-15 A mild catalytic system for radical conjugate addition of nitrogen heterocycles Aycock, R. A. Wang, H. Jui, N. T. Chem Sci Chemistry The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides. Royal Society of Chemistry 2017-04-01 2017-02-13 /pmc/articles/PMC5412691/ /pubmed/28507687 http://dx.doi.org/10.1039/c7sc00243b Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Aycock, R. A.
Wang, H.
Jui, N. T.
A mild catalytic system for radical conjugate addition of nitrogen heterocycles
title A mild catalytic system for radical conjugate addition of nitrogen heterocycles
title_full A mild catalytic system for radical conjugate addition of nitrogen heterocycles
title_fullStr A mild catalytic system for radical conjugate addition of nitrogen heterocycles
title_full_unstemmed A mild catalytic system for radical conjugate addition of nitrogen heterocycles
title_short A mild catalytic system for radical conjugate addition of nitrogen heterocycles
title_sort mild catalytic system for radical conjugate addition of nitrogen heterocycles
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412691/
https://www.ncbi.nlm.nih.gov/pubmed/28507687
http://dx.doi.org/10.1039/c7sc00243b
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