Patients With Long-QT Syndrome Caused by Impaired hERG-Encoded K(v)11.1 Potassium Channel Have Exaggerated Endocrine Pancreatic and Incretin Function Associated With Reactive Hypoglycemia

BACKGROUND: Loss-of-function mutations in hERG (encoding the K(v)11.1 voltage-gated potassium channel) cause long-QT syndrome type 2 (LQT2) because of prolonged cardiac repolarization. However, K(v)11.1 is also present in pancreatic α and β cells and intestinal L and K cells, secreting glucagon, ins...

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Detalles Bibliográficos
Autores principales: Hyltén-Cavallius, Louise, Iepsen, Eva W., Wewer Albrechtsen, Nicolai J., Svendstrup, Mathilde, Lubberding, Anniek F., Hartmann, Bolette, Jespersen, Thomas, Linneberg, Allan, Christiansen, Michael, Vestergaard, Henrik, Pedersen, Oluf, Holst, Jens J., Kanters, Jørgen K., Hansen, Torben, Torekov, Signe S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412733/
https://www.ncbi.nlm.nih.gov/pubmed/28235848
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024279

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