Central nervous system involvement of acute promyelocytic leukemia, three case reports

Central nervous system (CNS) involvement of acute promyelocytic leukemia (APL) causes poor prognosis. Our three cases show that CNS can be involved at the first hematological recurrence, but predicting this is difficult. Triple intrathecal treatment and craniospinal irradiation were effective, while...

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Autores principales: Furuya, Aya, Kawahara, Masahiro, Kumode, Mina, Ohira, Yasuyuki, Usui, Asako, Nagai, Shiho, Hosoba, Sakura, Minamiguchi, Hitoshi, Kito, Katsuyuki, Andoh, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412762/
https://www.ncbi.nlm.nih.gov/pubmed/28469869
http://dx.doi.org/10.1002/ccr3.919
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author Furuya, Aya
Kawahara, Masahiro
Kumode, Mina
Ohira, Yasuyuki
Usui, Asako
Nagai, Shiho
Hosoba, Sakura
Minamiguchi, Hitoshi
Kito, Katsuyuki
Andoh, Akira
author_facet Furuya, Aya
Kawahara, Masahiro
Kumode, Mina
Ohira, Yasuyuki
Usui, Asako
Nagai, Shiho
Hosoba, Sakura
Minamiguchi, Hitoshi
Kito, Katsuyuki
Andoh, Akira
author_sort Furuya, Aya
collection PubMed
description Central nervous system (CNS) involvement of acute promyelocytic leukemia (APL) causes poor prognosis. Our three cases show that CNS can be involved at the first hematological recurrence, but predicting this is difficult. Triple intrathecal treatment and craniospinal irradiation were effective, while arsenic oxide failed to prevent and improve CNS involvement.
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spelling pubmed-54127622017-05-03 Central nervous system involvement of acute promyelocytic leukemia, three case reports Furuya, Aya Kawahara, Masahiro Kumode, Mina Ohira, Yasuyuki Usui, Asako Nagai, Shiho Hosoba, Sakura Minamiguchi, Hitoshi Kito, Katsuyuki Andoh, Akira Clin Case Rep Case Reports Central nervous system (CNS) involvement of acute promyelocytic leukemia (APL) causes poor prognosis. Our three cases show that CNS can be involved at the first hematological recurrence, but predicting this is difficult. Triple intrathecal treatment and craniospinal irradiation were effective, while arsenic oxide failed to prevent and improve CNS involvement. John Wiley and Sons Inc. 2017-03-29 /pmc/articles/PMC5412762/ /pubmed/28469869 http://dx.doi.org/10.1002/ccr3.919 Text en © 2017 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Furuya, Aya
Kawahara, Masahiro
Kumode, Mina
Ohira, Yasuyuki
Usui, Asako
Nagai, Shiho
Hosoba, Sakura
Minamiguchi, Hitoshi
Kito, Katsuyuki
Andoh, Akira
Central nervous system involvement of acute promyelocytic leukemia, three case reports
title Central nervous system involvement of acute promyelocytic leukemia, three case reports
title_full Central nervous system involvement of acute promyelocytic leukemia, three case reports
title_fullStr Central nervous system involvement of acute promyelocytic leukemia, three case reports
title_full_unstemmed Central nervous system involvement of acute promyelocytic leukemia, three case reports
title_short Central nervous system involvement of acute promyelocytic leukemia, three case reports
title_sort central nervous system involvement of acute promyelocytic leukemia, three case reports
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412762/
https://www.ncbi.nlm.nih.gov/pubmed/28469869
http://dx.doi.org/10.1002/ccr3.919
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