Cargando…
The linear ubiquitin chain assembly complex regulates TRAIL‐induced gene activation and cell death
The linear ubiquitin chain assembly complex (LUBAC) is the only known E3 ubiquitin ligase which catalyses the generation of linear ubiquitin linkages de novo. LUBAC is a crucial component of various immune receptor signalling pathways. Here, we show that LUBAC forms part of the TRAIL‐R‐associated co...
Autores principales: | Lafont, Elodie, Kantari‐Mimoun, Chahrazade, Draber, Peter, De Miguel, Diego, Hartwig, Torsten, Reichert, Matthias, Kupka, Sebastian, Shimizu, Yutaka, Taraborrelli, Lucia, Spit, Maureen, Sprick, Martin R, Walczak, Henning |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412822/ https://www.ncbi.nlm.nih.gov/pubmed/28258062 http://dx.doi.org/10.15252/embj.201695699 |
Ejemplares similares
-
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes
por: Draber, Peter, et al.
Publicado: (2015) -
Linear ubiquitination in immunity
por: Shimizu, Yutaka, et al.
Publicado: (2015) -
The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2
por: Hartwig, Torsten, et al.
Publicado: (2017) -
The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis
por: Shimizu, Yutaka, et al.
Publicado: (2017) -
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
por: Taraborrelli, Lucia, et al.
Publicado: (2018)