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Association between subchondral bone structure and osteoarthritis histopathological grade

Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone structure compared to cartilage degeneration. This study linked structural adaptation of subchondral bone with histological OA grade. Twenty‐five osteochondr...

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Autores principales: Finnilä, Mikko A. J., Thevenot, Jérôme, Aho, Olli‐Matti, Tiitu, Virpi, Rautiainen, Jari, Kauppinen, Sami, Nieminen, Miika T., Pritzker, Kenneth, Valkealahti, Maarit, Lehenkari, Petri, Saarakkala, Simo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412847/
https://www.ncbi.nlm.nih.gov/pubmed/27227565
http://dx.doi.org/10.1002/jor.23312
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author Finnilä, Mikko A. J.
Thevenot, Jérôme
Aho, Olli‐Matti
Tiitu, Virpi
Rautiainen, Jari
Kauppinen, Sami
Nieminen, Miika T.
Pritzker, Kenneth
Valkealahti, Maarit
Lehenkari, Petri
Saarakkala, Simo
author_facet Finnilä, Mikko A. J.
Thevenot, Jérôme
Aho, Olli‐Matti
Tiitu, Virpi
Rautiainen, Jari
Kauppinen, Sami
Nieminen, Miika T.
Pritzker, Kenneth
Valkealahti, Maarit
Lehenkari, Petri
Saarakkala, Simo
author_sort Finnilä, Mikko A. J.
collection PubMed
description Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone structure compared to cartilage degeneration. This study linked structural adaptation of subchondral bone with histological OA grade. Twenty‐five osteochondral samples of macroscopically different degeneration were prepared from tibiae of 14 patients. Samples were scanned with micro‐computed tomography (μCT) and both conventional structural parameters and novel 3D parameters based on local patterns were analyzed from the subchondral plate and trabecular bone. Subsequently, samples were processed for histology and evaluated for OARSI grade. Each bone parameter and OARSI grade was compared to assess structural adaptation of bone with OA severity. In addition, thicknesses of cartilage, calcified cartilage, and subchondral plate were analyzed from histological sections and compared with subchondral bone plate thickness from μCT. With increasing OARSI grade, the subchondral plate became thicker along with decreased specific bone surface, while there was no change in tissue mineral density. Histological analysis showed that subchondral plate thickness from μCT also includes calcified cartilage. Entropy of local patterns increased with OA severity, reflecting higher tissue heterogeneity. In the trabecular compartment, bone volume fraction and both trabecular thickness and number increased with OARSI grade while trabecular separation and structure model index decreased. Also, elevation of local patterns became longitudinal in the subchondral plate and axial transverse in trabecular bone with increasing OARSI grade. This study demonstrates the possibility of radiological assessment of OA severity by structural analysis of bone. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. J Orthop Res 35:785–792, 2017.
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spelling pubmed-54128472017-05-15 Association between subchondral bone structure and osteoarthritis histopathological grade Finnilä, Mikko A. J. Thevenot, Jérôme Aho, Olli‐Matti Tiitu, Virpi Rautiainen, Jari Kauppinen, Sami Nieminen, Miika T. Pritzker, Kenneth Valkealahti, Maarit Lehenkari, Petri Saarakkala, Simo J Orthop Res Research Articles Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone structure compared to cartilage degeneration. This study linked structural adaptation of subchondral bone with histological OA grade. Twenty‐five osteochondral samples of macroscopically different degeneration were prepared from tibiae of 14 patients. Samples were scanned with micro‐computed tomography (μCT) and both conventional structural parameters and novel 3D parameters based on local patterns were analyzed from the subchondral plate and trabecular bone. Subsequently, samples were processed for histology and evaluated for OARSI grade. Each bone parameter and OARSI grade was compared to assess structural adaptation of bone with OA severity. In addition, thicknesses of cartilage, calcified cartilage, and subchondral plate were analyzed from histological sections and compared with subchondral bone plate thickness from μCT. With increasing OARSI grade, the subchondral plate became thicker along with decreased specific bone surface, while there was no change in tissue mineral density. Histological analysis showed that subchondral plate thickness from μCT also includes calcified cartilage. Entropy of local patterns increased with OA severity, reflecting higher tissue heterogeneity. In the trabecular compartment, bone volume fraction and both trabecular thickness and number increased with OARSI grade while trabecular separation and structure model index decreased. Also, elevation of local patterns became longitudinal in the subchondral plate and axial transverse in trabecular bone with increasing OARSI grade. This study demonstrates the possibility of radiological assessment of OA severity by structural analysis of bone. © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. J Orthop Res 35:785–792, 2017. John Wiley and Sons Inc. 2016-06-22 2017-04 /pmc/articles/PMC5412847/ /pubmed/27227565 http://dx.doi.org/10.1002/jor.23312 Text en © 2016 The Authors. Journal of Orthopaedic Research Published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Finnilä, Mikko A. J.
Thevenot, Jérôme
Aho, Olli‐Matti
Tiitu, Virpi
Rautiainen, Jari
Kauppinen, Sami
Nieminen, Miika T.
Pritzker, Kenneth
Valkealahti, Maarit
Lehenkari, Petri
Saarakkala, Simo
Association between subchondral bone structure and osteoarthritis histopathological grade
title Association between subchondral bone structure and osteoarthritis histopathological grade
title_full Association between subchondral bone structure and osteoarthritis histopathological grade
title_fullStr Association between subchondral bone structure and osteoarthritis histopathological grade
title_full_unstemmed Association between subchondral bone structure and osteoarthritis histopathological grade
title_short Association between subchondral bone structure and osteoarthritis histopathological grade
title_sort association between subchondral bone structure and osteoarthritis histopathological grade
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412847/
https://www.ncbi.nlm.nih.gov/pubmed/27227565
http://dx.doi.org/10.1002/jor.23312
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