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Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects
X‐ray crystal structures of three Λ‐[Ru(L)(2)dppz](2+) complexes (dppz=dipyridophenazine; L=1,10‐phenanthroline (phen), 2,2′‐bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5′‐CG‐3′ step. The compounds bind through canted intercalation, with the binding angle dete...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412927/ https://www.ncbi.nlm.nih.gov/pubmed/28105682 http://dx.doi.org/10.1002/chem.201605508 |
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author | Hall, James P. Gurung, Sarah P. Henle, Jessica Poidl, Patrick Andersson, Johanna Lincoln, Per Winter, Graeme Sorensen, Thomas Cardin, David J. Brazier, John A. Cardin, Christine J. |
author_facet | Hall, James P. Gurung, Sarah P. Henle, Jessica Poidl, Patrick Andersson, Johanna Lincoln, Per Winter, Graeme Sorensen, Thomas Cardin, David J. Brazier, John A. Cardin, Christine J. |
author_sort | Hall, James P. |
collection | PubMed |
description | X‐ray crystal structures of three Λ‐[Ru(L)(2)dppz](2+) complexes (dppz=dipyridophenazine; L=1,10‐phenanthroline (phen), 2,2′‐bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5′‐CG‐3′ step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH(2) group, in contrast to symmetrical intercalation previously observed at 5′‐TA‐3′ sites. This result suggests that canted intercalation is preferred at 5′‐CG‐3′ sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5′‐CG‐3′ step could give rise to a longer luminescence lifetime than canted intercalation. |
format | Online Article Text |
id | pubmed-5412927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54129272017-05-15 Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects Hall, James P. Gurung, Sarah P. Henle, Jessica Poidl, Patrick Andersson, Johanna Lincoln, Per Winter, Graeme Sorensen, Thomas Cardin, David J. Brazier, John A. Cardin, Christine J. Chemistry Communications X‐ray crystal structures of three Λ‐[Ru(L)(2)dppz](2+) complexes (dppz=dipyridophenazine; L=1,10‐phenanthroline (phen), 2,2′‐bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5′‐CG‐3′ step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH(2) group, in contrast to symmetrical intercalation previously observed at 5′‐TA‐3′ sites. This result suggests that canted intercalation is preferred at 5′‐CG‐3′ sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5′‐CG‐3′ step could give rise to a longer luminescence lifetime than canted intercalation. John Wiley and Sons Inc. 2017-02-06 2017-04-11 /pmc/articles/PMC5412927/ /pubmed/28105682 http://dx.doi.org/10.1002/chem.201605508 Text en © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Communications Hall, James P. Gurung, Sarah P. Henle, Jessica Poidl, Patrick Andersson, Johanna Lincoln, Per Winter, Graeme Sorensen, Thomas Cardin, David J. Brazier, John A. Cardin, Christine J. Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects |
title | Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects |
title_full | Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects |
title_fullStr | Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects |
title_full_unstemmed | Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects |
title_short | Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects |
title_sort | guanine can direct binding specificity of ru–dipyridophenazine (dppz) complexes to dna through steric effects |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412927/ https://www.ncbi.nlm.nih.gov/pubmed/28105682 http://dx.doi.org/10.1002/chem.201605508 |
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