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Osimertinib administration via nasogastric tube in an EGFR‐T790M‐positive patient with leptomeningeal metastases
Patients with an epidermal growth factor receptor (EGFR) mutation are usually administered EGFR‐tyrosine kinase inhibitors (TKIs) as standard‐of‐care treatment. However, acquired resistance occurs between 9 and 13 months. The T790M‐resistant mutations are the most common, and osimertinib has been fo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412970/ https://www.ncbi.nlm.nih.gov/pubmed/28469919 http://dx.doi.org/10.1002/rcr2.241 |
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author | Takeda, Takayuki Itano, Hideki Takeuchi, Mayumi Nishimi, Yurika Saitoh, Masahiko Takeda, Sorou |
author_facet | Takeda, Takayuki Itano, Hideki Takeuchi, Mayumi Nishimi, Yurika Saitoh, Masahiko Takeda, Sorou |
author_sort | Takeda, Takayuki |
collection | PubMed |
description | Patients with an epidermal growth factor receptor (EGFR) mutation are usually administered EGFR‐tyrosine kinase inhibitors (TKIs) as standard‐of‐care treatment. However, acquired resistance occurs between 9 and 13 months. The T790M‐resistant mutations are the most common, and osimertinib has been found to be effective in treating EGFR‐T790M‐positive patients. A 73‐year‐old female lung cancer patient with an EGFR‐sensitizing mutation was receiving fourth‐line chemotherapy when she complained of anorexia, headache, and irritability. A lumbar puncture showed adenocarcinoma in the cerebrospinal fluid (CSF), which led to the diagnosis of leptomeningeal metastasis. Her performance status (PS) deteriorated quickly and she also developed dysphagia. The EGFR mutation testing of the CSF demonstrated L858R+T790M double mutations, and an osimertinib suspension was subsequently administered through a nasogastric tube. The PS improved to 1, oral intake became possible after 20 days, and further improvements were observed by gadolinium‐enhanced magnetic resonance imaging. The patient remains progression‐free for 10 months after osimertinib administration. |
format | Online Article Text |
id | pubmed-5412970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54129702017-05-03 Osimertinib administration via nasogastric tube in an EGFR‐T790M‐positive patient with leptomeningeal metastases Takeda, Takayuki Itano, Hideki Takeuchi, Mayumi Nishimi, Yurika Saitoh, Masahiko Takeda, Sorou Respirol Case Rep Case Reports Patients with an epidermal growth factor receptor (EGFR) mutation are usually administered EGFR‐tyrosine kinase inhibitors (TKIs) as standard‐of‐care treatment. However, acquired resistance occurs between 9 and 13 months. The T790M‐resistant mutations are the most common, and osimertinib has been found to be effective in treating EGFR‐T790M‐positive patients. A 73‐year‐old female lung cancer patient with an EGFR‐sensitizing mutation was receiving fourth‐line chemotherapy when she complained of anorexia, headache, and irritability. A lumbar puncture showed adenocarcinoma in the cerebrospinal fluid (CSF), which led to the diagnosis of leptomeningeal metastasis. Her performance status (PS) deteriorated quickly and she also developed dysphagia. The EGFR mutation testing of the CSF demonstrated L858R+T790M double mutations, and an osimertinib suspension was subsequently administered through a nasogastric tube. The PS improved to 1, oral intake became possible after 20 days, and further improvements were observed by gadolinium‐enhanced magnetic resonance imaging. The patient remains progression‐free for 10 months after osimertinib administration. John Wiley & Sons, Ltd 2017-05-02 /pmc/articles/PMC5412970/ /pubmed/28469919 http://dx.doi.org/10.1002/rcr2.241 Text en © 2017 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Case Reports Takeda, Takayuki Itano, Hideki Takeuchi, Mayumi Nishimi, Yurika Saitoh, Masahiko Takeda, Sorou Osimertinib administration via nasogastric tube in an EGFR‐T790M‐positive patient with leptomeningeal metastases |
title | Osimertinib administration via nasogastric tube in an EGFR‐T790M‐positive patient with leptomeningeal metastases |
title_full | Osimertinib administration via nasogastric tube in an EGFR‐T790M‐positive patient with leptomeningeal metastases |
title_fullStr | Osimertinib administration via nasogastric tube in an EGFR‐T790M‐positive patient with leptomeningeal metastases |
title_full_unstemmed | Osimertinib administration via nasogastric tube in an EGFR‐T790M‐positive patient with leptomeningeal metastases |
title_short | Osimertinib administration via nasogastric tube in an EGFR‐T790M‐positive patient with leptomeningeal metastases |
title_sort | osimertinib administration via nasogastric tube in an egfr‐t790m‐positive patient with leptomeningeal metastases |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412970/ https://www.ncbi.nlm.nih.gov/pubmed/28469919 http://dx.doi.org/10.1002/rcr2.241 |
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