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Ectopic overexpression of LAPTM5 results in lysosomal targeting and induces Mcl-1 down-regulation, Bak activation, and mitochondria-dependent apoptosis in human HeLa cells

Human lysosomal-associated protein multispanning membrane 5 (LAPTM5) was identified by an ordered differential display-polymerase chain reaction (ODD-PCR) as an up-regulated cDNA fragment during 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced differentiation of U937 cells into monocytes/macrophag...

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Detalles Bibliográficos
Autores principales:	Jun, Do Youn, Kim, Hyejin, Jang, Won Young, Lee, Ji Young, Fukui, Kiyoshi, Kim, Young Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413007/ https://www.ncbi.nlm.nih.gov/pubmed/28464033 http://dx.doi.org/10.1371/journal.pone.0176544

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