The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness

The contribution of MEF2 TFs to the tumorigenic process is still mysterious. Here we clarify that MEF2 can support both pro-oncogenic or tumor suppressive activities depending on the interaction with co-activators or co-repressors partners. Through these interactions MEF2 supervise histone modificat...

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Detalles Bibliográficos
Autores principales: Di Giorgio, Eros, Franforte, Elisa, Cefalù, Sebastiano, Rossi, Sabrina, Dei Tos, Angelo Paolo, Brenca, Monica, Polano, Maurizio, Maestro, Roberta, Paluvai, Harikrishnareddy, Picco, Raffaella, Brancolini, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413110/
https://www.ncbi.nlm.nih.gov/pubmed/28419090
http://dx.doi.org/10.1371/journal.pgen.1006752

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